de Marchi, Stefano Fausto; Streuli, Sabina; Haefeli, Pascal; Gloekler, Steffen; Traupe, Tobias; Warncke, Cornelius; Rimoldi, Stefano F; Stortecky, Stefan; Steck, Hélène; Seiler, Christian (2012). Determinants of prognostically relevant intracoronary electrocardiogram ST-segment shift during coronary balloon occlusion. American journal of cardiology, 110(9), pp. 1234-1239. New York, N.Y.: Elsevier 10.1016/j.amjcard.2012.06.023
Full text not available from this repository.The prognostic relevance of quantitative an intracoronary occlusive electrocardiographic (ECG) ST-segment shift and its determinants have not been investigated in humans. In 765 patients with chronic stable coronary artery disease, the following simultaneous quantitative measurements were obtained during a 1-minute coronary balloon occlusion: intracoronary ECG ST-segment shift (recorded by angioplasty guidewire), mean aortic pressure, mean distal coronary pressure, and mean central venous pressure (CVP). Collateral flow index (CFI) was calculated as follows: (mean distal coronary pressure minus CVP)/(mean aortic pressure minus CVP). During an average follow-up duration of 50 ± 34 months, the cumulative mortality rate from all causes was significantly lower in the group with an ST-segment shift <0.1 mV (n = 89) than in the group with an ST-segment shift ≥0.1 mV (n = 676, p = 0.0211). Factors independently related to intracoronary occlusive ECG ST-segment shift <0.1 mV (r(2) = 0.189, p <0.0001) were high CFI (p <0.0001), intracoronary occlusive RR interval (p = 0.0467), right coronary artery as the ischemic region (p <0.0001), and absence of arterial hypertension (p = 0.0132). "High" CFI according to receiver operating characteristics analysis was ≥0.217 (area under receiver operating characteristics curve 0.647, p <0.0001). In conclusion, absence of ECG ST-segment shift during brief coronary occlusion in patients with chronic coronary artery disease conveys a decreased mortality and is directly influenced by a well-developed collateral supply to the right versus left coronary ischemic region and by the absence of systemic hypertension in a patient's history.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
De Marchi, Stefano, Traupe, Tobias, Rimoldi, Stefano, Stortecky, Stefan, Seiler, Christian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0002-9149 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
02 Mar 2023 23:21 |
Publisher DOI: |
10.1016/j.amjcard.2012.06.023 |
PubMed ID: |
22835408 |
Web of Science ID: |
000311003400005 |
URI: |
https://boris.unibe.ch/id/eprint/14984 (FactScience: 222133) |
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