Exercise training reverses exertional oscillatory ventilation in heart failure patients

Zurek, Marzena; Corrà, Ugo; Piepoli, Massimo F; Binder, Ronald K; Saner, Hugo; Schmid, Jean-Paul (2012). Exercise training reverses exertional oscillatory ventilation in heart failure patients. European respiratory journal, 40(5), pp. 1238-44. Sheffield, UK: European Respiratory Society 10.1183/09031936.00167011

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Exertional oscillatory ventilation (EOV) is an ominous prognostic sign in chronic heart failure (CHF), but little is known about the success of specific therapeutic interventions. Our aim was to study the impact of an exercise training on exercise capacity and cardiopulmonary adaptation in stable CHF patients with left ventricular systolic dysfunction and EOV. 96 stable CHF patients with EOV were included in a retrospective analysis (52 training versus 44 controls). EOV was defined as follows: 1) three or more oscillatory fluctuations in minute ventilation (V'(E)) during exercise; 2) regular oscillations; and 3) minimal average ventilation amplitude ≥5 L. EOV disappeared in 37 (71.2%) out of 52 patients after training, but only in one (2.3%) out of 44 without training (p<0.001). The decrease of EOV amplitude correlated with changes in end-tidal carbon dioxide tension (r= -0.60, p<0.001) at the respiratory compensation point and V'(E)/carbon dioxide production (V'(CO(2))) slope (r=0.50, p<0.001). Training significantly improved resting values of respiratory frequency (f(R)), V'(E), tidal volume (V(T)) and V'(E)/V'(CO(2)) ratio. During exercise, V'(E) and V(T) reached significantly higher values at the peak, while f(R) and V'(E)/V'(CO(2)) ratio were significantly lower at submaximal exercise. No change was noted in the control group. Exercise training leads to a significant decrease of EOV and improves ventilatory efficiency in patients with stable CHF.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Saner, Hugo Ernst, Schmid-Walker, Jean-Paul
ISSN:	0903-1936
Publisher:	European Respiratory Society
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:37
Last Modified:	02 Mar 2023 23:21
Publisher DOI:	10.1183/09031936.00167011
PubMed ID:	22408198
Web of Science ID:	000311461900026
URI:	https://boris.unibe.ch/id/eprint/14990 (FactScience: 222139)