Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time.

Weckmann, M; Thiele, D; Liboschik, L; Bahmer, T; Pech, M; Dittrich, A-M; Fuchs, O; Happle, C; Schaub, B; Ricklefs, I; Rabe, K F; von Mutius, E; Hansen, G; König, I R; Kopp, M V (2021). Cytokine levels in children and adults with wheezing and asthma show specific patterns of variability over time. Clinical and experimental immunology, 204(1), pp. 152-164. Wiley 10.1111/cei.13550

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Levels of cytokines are used for in-depth characterization of patients with asthma; however, the variability over time might be a critical confounder. To analyze the course of serum cytokines in children, adolescents and adults with asthma and in healthy controls and to propose statistical methods to control for seasonal effects. Of 532 screened subjects, 514 (91·5%) were included in the All Age Asthma Cohort (ALLIANCE). The cohort included 279 children with either recurrent wheezing bronchitis (more than two episodes) or doctor-diagnosed asthma, 75 healthy controls, 150 adult asthmatics and 31 adult healthy controls. Blood samples were collected and 25 μl serum was used for analysis with the Bio-Plex Pr human cytokine 27-Plex assay. Mean age, body mass index and gender in the three groups of wheezers, asthmatic children and adult asthmatics were comparable to healthy controls. Wheezers (34·5%), asthmatic children (78·7%) and adult asthmatics (62·8%) were significantly more often sensitized compared to controls (4·5, 22 and 22·6%, respectively). Considering the entire cohort, interleukin (IL)-1ra, IL-4, IL-9, IL-17, macrophage inflammatory protein (MIP)-1- and tumor necrosis factor (TNF)- showed seasonal variability, whereas IL-1β, IL-7, IL-8, IL-13, eotaxin, granulocyte colony-stimulating factor (G-CSF), interferon gamma-induced protein (IP)-10, MIP-1 and platelet-derived growth factor (PDGF)-BB did not. Significant differences between wheezers/asthmatics and healthy controls were observed for IL-17 and PDGF-BB, which remained stable after adjustment for the seasonality of IL-17. Seasonality has a significant impact on serum cytokine levels in patients with asthma. Because endotyping has achieved clinical importance to guide individualized patient-tailored therapy, it is important to account for seasonal effects.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Fuchs, Oliver, Kopp, Matthias Volkmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1365-2249

Publisher:

Wiley

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

19 Jan 2021 13:55

Last Modified:

05 Dec 2022 15:43

Publisher DOI:

10.1111/cei.13550

PubMed ID:

33202033

Uncontrolled Keywords:

adults asthma cytokines season: variability wheeze: children

BORIS DOI:

10.48350/150381

URI:

https://boris.unibe.ch/id/eprint/150381

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