Denhaerynck, Kris; Goldfarb-Rumyantzev, Alexander S; Sandhu, Gurprataap; Beckmann, Sonja; Huynh-Do, Uyen; Binet, Isabelle; De Geest, Sabina (2021). Pre-transplant Social Adaptability Index and clinical outcomes in renal transplantation - The Swiss Transplant Cohort Study. Clinical transplantation, 35(4), e14218. Wiley-Blackwell 10.1111/ctr.14218
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2020_STCS_Social_Adaptability_Index_Denhaerynck_Clin_Tpl_2020.pdf - Accepted Version Available under License Publisher holds Copyright. Download (335kB) | Preview |
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ctr.14218.pdf - Accepted Version Available under License Publisher holds Copyright. Download (9MB) | Preview |
BACKGROUND
The impact of pre-transplant social determinants of health on post-transplant outcomes remains understudied. In the US, poor clinical outcomes are associated with underprivileged status, as assessed by the Social Adaptability Index (SAI), a composite score of education, employment status, marital status, household income, and substance abuse. Using data from the Swiss Transplant Cohort Study (STCS), we determined the SAI's predictive value regarding two post-transplant outcomes: all-cause mortality and return to dialysis.
METHODS
Between 2012 and 2018, we included adult renal transplant patients (aged ≥18 years) with pre-transplant assessment SAI scores, calculated from a STCS Psychosocial Questionnaire. Time to all-cause mortality and return to dialysis were predicted using Cox regression.
RESULTS
Of 1238 included patients (mean age: 53.8±13.2 years; 37.9% female; median follow-up time: 4.4 years (IQR: 2.7)), 93 (7.5%) died and 57 (4.6%) returned to dialysis. The SAI's hazard ratio was 0.94 (95%CI: 0.88-1.01; p=0.09) for mortality and 0.93 (95%CI: 0.85-1.02; p=0.15) for return to dialysis.
CONCLUSIONS
In contrast to most published studies on social deprivation, analysis of this Swiss sample detected no significant association between SAI score and mortality or return to dialysis.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Huynh-Do, Uyen |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0902-0063 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Prof. Dr. Uyen Huynh-Do |
Date Deposited: |
05 Mar 2021 15:23 |
Last Modified: |
05 Dec 2022 15:48 |
Publisher DOI: |
10.1111/ctr.14218 |
PubMed ID: |
33406303 |
Uncontrolled Keywords: |
graft survival kidney transplantation mortality socioeconomic factors |
BORIS DOI: |
10.48350/152981 |
URI: |
https://boris.unibe.ch/id/eprint/152981 |
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