Transplantation of Ovarian Tissue

von Wolff, Michael (2020). Transplantation of Ovarian Tissue. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 203-213). Cham: Springer 10.1007/978-3-030-47568-0_23

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Cryopreserved ovarian tissue can be transplanted after a thawing process. An orthotopic transplantation, that is in or on the ovary or in the ovarian fossa seems to be ideal. It is still unclear which of these locations is best. At least 70% of grafts are endocrine active and form follicles after transplantation. According to current data, every fourth transplanted woman gives birth to a child. Two-third of the pregnancies occurred spontaneously after transplantation and one-third of the cases after ART. The life expectancy of the transplant is usually several years. Tissue can also be transplanted to avoid hormone replacement therapy in patients with premature ovarian insufficiency, but this is not advisable from an endocrinological point of view.

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