von Wolff, Michael (2020). Pregnancy After Chemotherapy and Pelvic Radiotherapy. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 269-271). Cham: Springer 10.1007/978-3-030-47568-0_30
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The effect of chemotherapy on a later pregnancy seems to be rather small. However, alkylating agents in childhood might have a negative effect on uterine function. The effect of radiotherapy depends strongly on the radiation intensity and the age at radiation exposure. Radiation during childhood seems to have a greater negative effect on the uterus than in adulthood. Radiotherapy to the adult uterus with whole-body radiation (12 Gy) is associated with an increased risk of abortion, premature birth and a low birth weight. If the uterus is irradiated with >25 Gy in childhood, pregnancy should not be recommended. If the uterus is irradiated with >45 Gy in adults, pregnancy should not be advised.
Item Type: |
Book Section (Book Chapter) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISBN: |
978-3-030-47567-3 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
16 Mar 2021 17:37 |
Last Modified: |
05 Dec 2022 15:49 |
Publisher DOI: |
10.1007/978-3-030-47568-0_30 |
BORIS DOI: |
10.48350/153987 |
URI: |
https://boris.unibe.ch/id/eprint/153987 |
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