Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up

Ziller, Volker; Stute, Petra; von Wolff, Michael (2020). Premature Ovarian Insufficiency: Hormone Replacement Therapy and Follow-Up. In: von Wolff, Michael; Nawroth, Frank (eds.) Fertility Preservation in Oncological and Non-Oncological Diseases (pp. 273-282). Cham: Springer 10.1007/978-3-030-47568-0_31

Text Ziller2020_Chapter_PrematureOvarianInsufficiencyH.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (333kB) | Request a copy

This chapter describes causes, diagnostic and therapeutic procedures in the event of premature ovarian insufficiency (POI) induced either by gonadotoxic treatments or caused by genetic defects, autoimmunological disease, infection, surgical interventions, etc. POI is defined by oligo-/amenorrhea for at least 4 months and a serum concentration of FSH > 25 IU/I measured twice at least 4 weeks apart in women before the age of 40 years. Women with POI generally show the typical symptoms of menopause such as cycle disorders, hot flushes, vaginal dryness, sleep disorders and psychological changes such as nervousness, irritability, fatigue and others. Fertility of POI patients is severely reduced and total infertility can occur. The lack of estrogen leads to considerable long-term consequences. These are primarily effects on bone metabolism, the cardiovascular system and changes in the nervous system that result in a reduced life expectancy. The misinterpretation of the WHI (Women’s Health Initiative) study has led to an irrational fear of hormone replacement therapy (HRT) for both patients and doctors. However, with the increased risk associated with POI/early menopause HRT is advantageous if the oncological and other contraindications to HRT are followed. The risks of non-HRT must therefore be weighed individually against the risks of HRT.

Interest & Impact

Downloads

1 since deposited on 16 Mar 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item