High altitude, a natural research laboratory for the study of cardiovascular physiology and pathophysiology

Scherrer, Urs; Allemann, Yves; Jayet, Pierre-Yves; Rexhaj, Emrush; Sartori, Claudio (2010). High altitude, a natural research laboratory for the study of cardiovascular physiology and pathophysiology. Progress in cardiovascular diseases, 52(6), pp. 451-5. Orlando, Fla.: Elsevier 10.1016/j.pcad.2010.02.002

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High altitude constitutes an exciting natural laboratory for medical research. Although initially, the aim of high-altitude research was to understand the adaption of the organism to hypoxia and find treatments for altitude-related diseases, during the past decade or so, the scope of this research has broadened considerably. Two important observations led the foundation for the broadening of the scientific scope of high-altitude research. First, high-altitude pulmonary edema represents a unique model that allows studying fundamental mechanisms of pulmonary hypertension and lung edema in humans. Second, the ambient hypoxia associated with high-altitude exposure facilitates the detection of pulmonary and systemic vascular dysfunction at an early stage. Here, we will review studies that, by capitalizing on these observations, have led to the description of novel mechanisms underpinning lung edema and pulmonary hypertension and to the first direct demonstration of fetal programming of vascular dysfunction in humans.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Allemann, Yves
ISSN:	0033-0620
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:10
Last Modified:	05 Dec 2022 14:01
Publisher DOI:	10.1016/j.pcad.2010.02.002
PubMed ID:	20417338
Web of Science ID:	000277309600002
URI:	https://boris.unibe.ch/id/eprint/1543 (FactScience: 203318)