European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years.

Gaillard, Erol A; Kuehni, Claudia E.; Turner, Steve; Goutaki, Myrofora; Holden, Karl A; de Jong, Carmen C M; Lex, Christiane; Lo, David K H; Lucas, Jane S; Midulla, Fabio; Mozun, Rebeca; Piacentini, Giorgio; Rigau, David; Rottier, Bart; Thomas, Mike; Tonia, Thomy; Usemann, Jakob; Yilmaz, Ozge; Zacharasiewicz, Angela and Moeller, Alexander (2021). European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years. European respiratory journal, 58(5), p. 2004173. European Respiratory Society 10.1183/13993003.04173-2020

[img]
Preview
Text
Gaillard_EurRespirJ_2021_AAM.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (4MB) | Preview
[img] Text
Gaillard_EurRespirJ_2021.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (993kB)

Diagnosing asthma in children represents an important clinical challenge. There is no single gold standard test to confirm the diagnosis. Consequently, both over-, and under-diagnosis of asthma are frequent in children.A Task Force (TF) supported by the European Respiratory Society has developed these evidence-based clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years using nine PICO (Population, Intervention, Comparator and Outcome) questions. The TF conducted systematic literature searches for all PICO questions and screened the outputs from these, including relevant full text articles. All TF members approved the final decision for inclusion of research papers. The TF assessed the quality of the evidence using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach.The TF then developed a diagnostic algorithm based on the critical appraisal of the PICO questions, preferences expressed by lay members and test availability. Proposed cut-offs were determined based on the best available evidence. The TF formulated recommendations using the GRADE Evidence to Decision framework.Based on the critical appraisal of the evidence and the Evidence to Decision Framework the TF recommends spirometry, bronchodilator reversibility testing and FeNO as first line diagnostic tests in children under investigation for asthma. The TF recommends against diagnosing asthma in children based on clinical history alone or following a single abnormal objective test. Finally, this guideline also proposes a set of research priorities to improve asthma diagnosis in children in the future.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Kühni, Claudia, Goutaki, Myrofora, de Jong, Carmen Cornelia Maria, Mozún Torrico, Rebeca, Tonia, Thomai

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

28 Apr 2021 10:48

Last Modified:

05 Dec 2022 15:50

Publisher DOI:

10.1183/13993003.04173-2020

PubMed ID:

33863747

BORIS DOI:

10.48350/155972

URI:

https://boris.unibe.ch/id/eprint/155972

Actions (login required)

Edit item Edit item
Provide Feedback