Diem, L.; Hoepner, R.; Bagnoud, M.; Salmen, A.; Chan, A.; Friedli, C. (2021). Natalizumab induced blood eosinophilia: A retrospective pharmacovigilance cohort study and review of the literature. Journal of neuroimmunology, 353, p. 577505. Elsevier 10.1016/j.jneuroim.2021.577505
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OBJECTIVE
To describe frequency of natalizumab related eosinophilia and clinical symptoms of eosinophilic disease in our monocentric cohort.
METHODS
Comparison of clinical characteristics of 115 natalizumab treated and 116 untreated RRMS patients and review of literature.
RESULTS
38% of natalizumab treated patients had eosinophilia, which occurred significantly more frequently compared to untreated MS patients (3%, p-value<0.001). In symptomatic patients, mean eosinophil counts were significantly higher than in asymptomatic patients and symptoms developed within one year.
DISCUSSION
Eosinophilia is a side effect of natalizumab and mostly asymptomatic. However, few patients develop within one year after start of natalizumab an eosinophilic disease as severe side effect.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Diem, Lara, Hoepner, Robert, Bagnoud, Maud Marie, Salmen, Anke, Chan, Andrew Hao-Kuang, Friedli, Christoph Daniel |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0165-5728 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
30 Jun 2021 12:22 |
Last Modified: |
05 Dec 2022 15:51 |
Publisher DOI: |
10.1016/j.jneuroim.2021.577505 |
PubMed ID: |
33548621 |
Uncontrolled Keywords: |
Immunotherapy Multiple sclerosis Natalizumab Pulmonary eosinophilia Side effects |
BORIS DOI: |
10.48350/157139 |
URI: |
https://boris.unibe.ch/id/eprint/157139 |
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