Safety of diagnostic balloon occlusion in normal coronary arteries

Gloekler, Steffen; Traupe, Tobias; Meier, Pascal; Steck, Hélène; de Marchi, Stefano F.; Seiler, Christian (2010). Safety of diagnostic balloon occlusion in normal coronary arteries. American journal of cardiology, 105(12), pp. 1716-1722. New York, N.Y.: Elsevier 10.1016/j.amjcard.2010.01.350

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Diagnostic coronary balloon occlusion (CBO) is mandatory for collateral function assessment, during angioscopy and optical coherence imaging, and when using certain coronary protection devices against emboli. Thus far, the safety of diagnostic CBO regarding procedural and long-term complications in normal coronary arteries has not been studied. In 316 patients, diagnostic CBO was performed for collateral function measurement in 426 angiographically normal vessels. The angioplasty balloon was inflated for 60 to 120 seconds using inflation pressures of 1 to 3 atm, followed by control angiography during and after CBO. Patients were divided into groups with entirely normal (n = 133) and partially normal (n = 183) vessels. Primary end points were procedural and long-term complications. De novo stenosis development was assessed by quantitative coronary angiography in 35% of the patients. Secondary end points were cardiac events at 5 years of follow-up. Procedural complications occurred in 1 patient (0.2%). In 150 repeat angiographic procedures in 92 patients (follow-up duration 10 +/- 15 months), quantitative coronary angiography revealed no difference in percentage diameter narrowing between baseline and follow-up (4.1% vs 3.9%, p = 0.69). During follow-up periods of 14 and 72 months, respectively, a new stenotic lesion was detected in 1 patient in each group (1.3%). Major cardiac events and percutaneous coronary intervention for stable angina were less frequent in the group with entirely normal than with partially normal vessels (0.8% vs 5.5%, p = 0.02, and 0.8% vs 18%, p <0.0001). In conclusion, low-inflation pressure diagnostic CBO in angiographically normal coronary arteries bears a minimal risk for procedural and long-term complications and can therefore be regarded as a safe procedure.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Glökler, Steffen, Traupe, Tobias, De Marchi, Stefano, Seiler, Christian
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0002-9149
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:10
Last Modified:	02 Mar 2023 23:20
Publisher DOI:	10.1016/j.amjcard.2010.01.350
PubMed ID:	20538120
Web of Science ID:	000279378100012
URI:	https://boris.unibe.ch/id/eprint/1572 (FactScience: 203348)