The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents.

Bartkowiak, Joanna; Spitzer, Ernest; Kurmann, Reto; Zürcher, Fabian Johann; Krähenmann, Peter; Garcia-Ruiz, Victoria; Mercado, Jorge; Ryffel, Christoph; Losdat, Sylvain; Llerena, Nassip; Torres, Pedro; Lanz, Jonas; Stocker, Martin; Ren, Ben; Glöckler, Martin; Pilgrim, Thomas (2021). The impact of obesity on left ventricular hypertrophy and diastolic dysfunction in children and adolescents. Scientific Reports, 11(1), p. 13022. Nature Publishing Group 10.1038/s41598-021-92463-x

[img]
Preview
Text
Bartkowiak_SciRep_2021.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

Childhood obesity continues to escalate worldwide and may affect left ventricular (LV) geometry and function. The aim of this study was to investigate the impact of obesity on prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction in children. In this analysis of prospectively collected cross-sectional data of children between 5 and 16 years of age from randomly selected schools in Peru, parameters of LV geometry and function were compared according to presence or absence of obesity (body mass index z-score > 2). LVH was based on left ventricular mass index (LVMI) adjusted for age and sex and defined by a z-score of > 2. LV diastolic function was assessed using mitral inflow early-to-late diastolic flow (E/A) ratio, peak early diastolic tissue velocities of the lateral mitral annulus (E'), early diastolic transmitral flow velocity to tissue Doppler mitral annular early diastolic velocity (E/E') ratio, and left atrial volume index (LAVI). Among 1023 children, 681 children (mean age 12.2 ± 3.1 years, 341 male (50.1%)) were available for the present analysis, of which 150 (22.0%) were obese. LVH was found in 21 (14.0%) obese and in 19 (3.6%) non-obese children (padjusted < 0.001). LVMI was greater in obese than that in non-obese children (36.1 ± 8.6 versus 28.7 ± 6.9 g/m2.7, p < 0.001). The mean mitral E/E' ratio and LAVI were significantly higher in obese than those in non-obese individuals (E/E': 5.2 ± 1.1 versus 4.9 ± 0.8, padjusted = 0.043; LAVI 11.0 ± 3.2 versus 9.6 ± 2.9, padjusted = 0.001), whereas E' and E/A ratio were comparable. Childhood obesity was associated with left ventricular hypertrophy and determinants of diastolic dysfunction.ClinicalTrials.gov Identifier: NCT02353663.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Pre-clinic Human Medicine > Department of Clinical Research (DCR)

UniBE Contributor:

Bartkowiak, Joanna, Zürcher, Fabian Johann, Ryffel, Christoph Philippe, Losdat, Sylvain Pierre, Lanz, Jonas, Glöckler, Martin, Pilgrim, Thomas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

29 Jun 2021 20:09

Last Modified:

20 Feb 2024 14:16

Publisher DOI:

10.1038/s41598-021-92463-x

PubMed ID:

34158575

BORIS DOI:

10.48350/157214

URI:

https://boris.unibe.ch/id/eprint/157214

Actions (login required)

Edit item Edit item
Provide Feedback