Wolf-Schnurrbusch, Ute E. K.; Hess, Roberto; Jordi, Florian; Stuck, Anna; Sarra, Gian-Marco; Wolf, Sebastian; Enzmann, Volker (2013). Detection of Chlamydia and complement factors in neovascular membranes of patients with age-related macular degeneration. Ocular immunology and inflammation, 21(1), pp. 36-43. New York, N.Y.: Informa Healthcare 10.3109/09273948.2012.726393
Full text not available from this repository.PURPOSE
To investigate whether Chlamydia pneumoniae and complement factors were present in surgically removed choroidal neovascular membranes (CNV) of patients with age-related macular degeneration (AMD).
METHODS
Paraffin sections of 26 CNV were stained for C. pneumoniae or the complement factors H (CFH) and C5, whereas macrophages were identified by positive CD68 staining. Clinical characteristics have been correlated to the immunohistochemical findings.
RESULTS
C. pneumoniae was found in 68% of the investigated membranes, and 88% of these membranes were also positive for CD68. Staining for CFH and C5 gave a positive reaction in 68 and 41% of the membranes, respectively. Patients with C5-positive membranes had significantly larger CNV mean area and were younger than patients with CFH-positive membranes at the operation time point.
CONCLUSIONS
Correlations between clinical symptoms and complement factor C5 could be shown. The results strengthen the hypothesis of an involvement of the complement system in AMD.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 04 Faculty of Medicine > Service Sector > Institute of Pathology > Autopsy |
UniBE Contributor: |
Wolf-Schnurrbusch, Ute, Hess, Roberto, Eggimann, Anna, Sarra, Gian-Marco, Wolf, Sebastian (B), Enzmann, Volker |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0927-3948 |
Publisher: |
Informa Healthcare |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:39 |
Last Modified: |
05 Dec 2022 14:12 |
Publisher DOI: |
10.3109/09273948.2012.726393 |
PubMed ID: |
23590149 |
URI: |
https://boris.unibe.ch/id/eprint/15837 (FactScience: 223313) |
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