Notter, Markus; Stutz, Emanuel; Thomsen, Andreas R; Vaupel, Peter (2021). Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation. Cancers, 13(15) MDPI AG 10.3390/cancers13153911
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BACKGROUND
Radiation-associated angiosarcoma of the breast (RAASB) is a rare, challenging disease, with surgery being the accepted basic therapeutic approach. In contrast, the role of adjuvant and systemic therapies is a subject of some controversy. Local recurrence rates reported in the literature are mostly heterogeneous and are highly dependent on the extent of surgery. In cases of locally recurrent or unresectable RAASB, prognosis is very poor.
METHODS
We retrospectively report on 10 consecutive RAASB patients, most of them presenting with locally recurrent or unresectable RAASB, which were treated with thermography-controlled water-filtered infrared-A (wIRA) superficial hyperthermia (HT) immediately followed by re-irradiation (re-RT). Patients with RAASB were graded based on their tumor extent before onset of radiotherapy (RT).
RESULTS
We recorded a local control (LC) rate dependent on tumor extent ranging from a high LC rate of 100% (two of two patients) in the adjuvant setting with an R0 or R2 resection to a limited LC rate of 33% (one of three patients) in patients with inoperable, macroscopic tumor lesions.
CONCLUSION
Combined HT and re-RT should be considered as an option (a) for adjuvant treatment of RAASB, especially in cases with positive resection margins and after surgery of local recurrence (LR), and (b) for definitive treatment of unresectable RAASB.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology |
UniBE Contributor: |
Stutz, Emanuel |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Beatrice Scheidegger |
Date Deposited: |
13 Sep 2021 07:39 |
Last Modified: |
05 Dec 2022 15:52 |
Publisher DOI: |
10.3390/cancers13153911 |
PubMed ID: |
34359812 |
Uncontrolled Keywords: |
radiation-associated angiosarcoma of the breast re-irradiation secondary angiosarcoma superficial hyperthermia wIRA-hyperthermia |
BORIS DOI: |
10.48350/158379 |
URI: |
https://boris.unibe.ch/id/eprint/158379 |
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