Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame.

Benowitz, Neal L; St Helen, Gideon; Liakoni, Evangelia (2021). Clinical Pharmacology of Electronic Nicotine Delivery Systems (ENDS): Implications for Benefits and Risks in the Promotion of the Combusted Tobacco Endgame. Journal of clinical pharmacology, 61(Suppl 2), S18-S36. Sage Science Press 10.1002/jcph.1915

[img] Text
Benowitz__J_Clin_Pharmacol_2021.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (1MB)

Electronic nicotine delivery systems (ENDS) such as e-cigarettes and heated tobacco products are novel battery-operated devices that deliver nicotine without combustion of tobacco. Because cigarette smoking is sustained by nicotine addiction and the toxic combustion products are mainly responsible for the harmful effects of smoking, ENDS could be used to promote smoking cessation while exposing users to lower levels of toxicants compared with conventional cigarettes. The currently available evidence from clinical and observational studies indicates a potential role of e-cigarettes as smoking cessation aids, although many continue to use e-cigarettes long after quitting smoking. Nicotine and toxicant delivery vary considerably by device and depend on the characteristics of the e-liquid formulation. Because smokers tend to titrate their nicotine intake to maintain their desired pharmacologic effects, device and liquid characteristics need to be considered when using ENDS as an aid to quit smoking. Factors potentially limiting their use are the currently still unknown long-term safety of these products and concerns regarding widespread use among youth. Implications of clinical pharmacology data on ENDS for the cigarette endgame and regulation by the U.S. Food and Drug administration are discussed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine

UniBE Contributor:

Liakoni, Evangelia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0091-2700

Publisher:

Sage Science Press

Language:

English

Submitter:

Tobias Tritschler

Date Deposited:

07 Sep 2021 16:52

Last Modified:

05 Dec 2022 15:53

Publisher DOI:

10.1002/jcph.1915

PubMed ID:

34396553

Uncontrolled Keywords:

e-cigarettes electronic nicotine delivery heat-not-burn nicotine tobacco

BORIS DOI:

10.48350/158991

URI:

https://boris.unibe.ch/id/eprint/158991

Actions (login required)

Edit item Edit item
Provide Feedback