Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts.

de Gouveia Belinelo, Patricia; Collison, Adam M; Murphy, Vanessa E; Robinson, Paul D; Jesson, Kathryn; Hardaker, Kate; de Queiroz Andrade, Ediane; Oldmeadow, Christopher; Martins Costa Gomes, Gabriela; Sly, Peter D; Usemann, Jakob; Appenzeller, Rhea; Gorlanova, Olga; Fuchs, Oliver; Latzin, Philipp; Gibson, Peter G; Frey, Urs; Mattes, Joerg (2021). Maternal asthma is associated with reduced lung function in male infants in a combined analysis of the BLT and BILD cohorts. Thorax, 76(10), pp. 996-1001. BMJ Publishing Group 10.1136/thoraxjnl-2020-215526

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RATIONALE

Asthma in pregnancy is associated with respiratory diseases in the offspring.

OBJECTIVE

To investigate if maternal asthma is associated with lung function in early life.

METHODS

Data on lung function measured at 5-6 weeks of age were combined from two large birth cohorts: the Bern Infant Lung Development (BILD) and the Australian Breathing for Life Trial (BLT) birth cohorts conducted at three study sites (Bern, Switzerland; Newcastle and Sydney, Australia). The main outcome variable was time to reach peak tidal expiratory flow as a percentage of total expiratory time(tPTEF:tE%). Bayesian linear hierarchical regression analyses controlling for study site as random effect were performed to estimate the effect of maternal asthma on the main outcome, adjusting for sex, birth order, breast feeding, weight gain and gestational age. In separate adjusted Bayesian models an interaction between maternal asthma and sex was investigated by including an interaction term.

MEASUREMENTS AND MAIN RESULTS

All 406 BLT infants were born to mothers with asthma in pregnancy, while 193 of the 213 (91%) BILD infants were born to mothers without asthma. A significant interaction between maternal asthma and male sex was negatively associated with tPTEF:tE% (intercept 37.5; estimate: -3.5; 95% credible interval -6.8 to -0.1). Comparing the model posterior probabilities provided decisive evidence in favour of an interaction between maternal asthma and male sex (Bayes factor 33.5).

CONCLUSIONS

Maternal asthma is associated with lower lung function in male babies, which may have lifelong implications on their lung function trajectories and future risk of wheezing and asthma.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Fuchs, Oliver, Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0040-6376

Publisher:

BMJ Publishing Group

Language:

English

Submitter:

Anette van Dorland

Date Deposited:

16 Sep 2021 11:40

Last Modified:

05 Dec 2022 15:53

Publisher DOI:

10.1136/thoraxjnl-2020-215526

PubMed ID:

33632766

Uncontrolled Keywords:

asthma paediatric lung disease respiratory measurement

BORIS DOI:

10.48350/159017

URI:

https://boris.unibe.ch/id/eprint/159017

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