Dysbiotic microbiota interactions in Crohn's disease.

Caparrós, Esther; Wiest, Reiner; Scharl, Michael; Rogler, Gerhard; Gutiérrez Casbas, Ana; Yilmaz, Bahtiyar; Wawrzyniak, Marcin; Francés, Rubén (2021). Dysbiotic microbiota interactions in Crohn's disease. Gut microbes, 13(1), p. 1949096. Landes Bioscience 10.1080/19490976.2021.1949096

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Crohn's disease (CD) is a major form of inflammatory bowel disease characterized by transmural inflammation along the alimentary tract. Changes in the microbial composition and reduction in species diversity are recognized as pivotal hallmarks in disease dynamics, challenging the gut barrier function and shaping a pathological immune response in genetically influenced subjects. The purpose of this review is to delve into the modification of the gut microbiota cluster network during CD progression and to discuss how this shift compromises the gut barrier integrity, granting the translocation of microbes and their products. We then complete the scope of the review by retracing gut microbiota dysbiosis interactions with the main pathophysiologic factors of CD, starting from the host's genetic background to the immune inflammatory and fibrotic processes, providing a standpoint on the lifestyle/exogenous factors and the potential benefits of targeting a specific gut microbiota.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Wiest, Reiner, Yilmaz, Bahtiyar (A)

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1949-0976

Publisher:

Landes Bioscience

Language:

English

Submitter:

Rahel Fuhrer

Date Deposited:

20 Sep 2021 14:16

Last Modified:

29 Mar 2024 22:39

Publisher DOI:

10.1080/19490976.2021.1949096

PubMed ID:

34313550

Uncontrolled Keywords:

Crohn’s disease bacterial translocation dysbiosis fibrosis inflammation microbiota

BORIS DOI:

10.48350/159103

URI:

https://boris.unibe.ch/id/eprint/159103

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