Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - is there a difference?

Leiherer, Andreas; Mündlein, Axel; Brandtner, Eva Maria; Säly, Christoph H; Ramadani, Hana; Vonbank, Alexander; Mader, Arthur; Dopheide, Jörn F.; Jylhä, Antti; Lääperi, Mitja; Laaksonen, Reijo; März, Winfried; Fraunberger, Peter; Kleber, Marcus; Drexel, Heinz (2021). Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - is there a difference? Journal of internal medicine, 290(6), pp. 1249-1263. Wiley 10.1111/joim.13368

Text LeihererA_LipidPOfPWithManifestCoronaryVsPerpheralAtherosclerosis-difference_JIM_2021.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (10MB)

AIM

Peripheral arterial disease (PAD) and coronary artery disease (CAD) are both caused by atherosclerosis. Serum lipids and lipoproteins are predictive of the development of atherosclerosis but it is not clear if they differ in the two manifestations PAD and CAD. We tested whether a more detailed characterization of the lipid and lipoprotein patterns of PAD and CAD allows a clear differentiation between the two atherosclerotic phenotypes.

METHODS

A cohort of 274 statin-naïve patients with either newly diagnosed imaging proven PAD (n = 89) or stable CAD (n = 185) was characterized using nuclear magnetic resonance- and liquid chromatography-tandem mass spectrometry-based advanced lipid and lipoprotein analysis. An independent cohort of 1239 patients with PAD and CAD was used for validation.

RESULTS

We found a significant difference in markers of inflammation as well as ceramide and phosphatidylcholine levels between PAD and CAD patients. In contrast, basic lipid markers including total cholesterol, LDL cholesterol, HDL cholesterol, lipoprotein(a) or detailed lipoprotein profiles did not differ significantly between PAD and CAD patients. Applying ratios and scores derived from ceramides and phosphatidylcholines further improved the discrimination between PAD and CAD. These significant differences were independent of body composition, from the status of smoking or T2DM, and also from apolipoprotein C-III and other inflammatory parameters which were different between CAD and PAD.

CONCLUSION

The present study clearly suggests that PAD and CAD differ in terms of their ceramide- and phosphatidylcholine-based lipid patterns but not in lipoprotein characteristics.

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