ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research

Odening, Katja E.; Gomez, Ana-Maria; Dobrev, Dobromir; Fabritz, Larissa; Heinzel, Frank R; Mangoni, Matteo E; Molina, Cristina E; Sacconi, Leonardo; Smith, Godfrey; Stengl, Milan; Thomas, Dierk; Zaza, Antonio; Remme, Carol Ann; Heijman, Jordi (2021). ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research. EP Europace, 23(11), pp. 1795-1814. Oxford University Press 10.1093/europace/euab142

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Cardiac arrhythmias are a major cause of death and disability. A large number of experimental cell and animal models have been developed to study arrhythmogenic diseases. These models have provided important insights into the underlying arrhythmia mechanisms and translational options for their therapeutic management. This position paper from the ESC Working Group on Cardiac Cellular Electrophysiology provides an overview of (i) currently available in vitro, ex vivo, and in vivo electrophysiological research methodologies, (ii) the most commonly used experimental (cellular and animal) models for cardiac arrhythmias including relevant species differences, (iii) the use of human cardiac tissue, induced pluripotent stem cell (hiPSC)-derived and in silico models to study cardiac arrhythmias, and (iv) the availability, relevance, limitations, and opportunities of these cellular and animal models to recapitulate specific acquired and inherited arrhythmogenic diseases, including atrial fibrillation, heart failure, cardiomyopathy, myocarditis, sinus node, and conduction disorders and channelopathies. By promoting a better understanding of these models and their limitations, this position paper aims to improve the quality of basic research in cardiac electrophysiology, with the ultimate goal to facilitate the clinical translation and application of basic electrophysiological research findings on arrhythmia mechanisms and therapies.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Physiology
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Odening, Katja Elisabeth

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1099-5129

Publisher:

Oxford University Press

Language:

English

Submitter:

Stefan von Känel-Zimmermann

Date Deposited:

22 Oct 2021 12:07

Last Modified:

05 Dec 2022 15:53

Publisher DOI:

10.1093/europace/euab142

PubMed ID:

34313298

BORIS DOI:

10.48350/159874

URI:

https://boris.unibe.ch/id/eprint/159874

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