Jäger, Tim; Holandino, Carla; Melo, Michelle Nonato de Oliveira; Peñaloza, Evelyn Maribel Condori; Oliveira, Adriana Passos; Garrett, Rafael; Glauser, Gaétan; Grazi, Mirio; Ramm, Hartmut; Urech, Konrad; Baumgartner, Stephan (2021). Metabolomics by UHPLC-Q-TOF Reveals Host Tree-Dependent Phytochemical Variation in Viscum album L. Plants, 10(8) MDPI 10.3390/plants10081726
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Viscum album L., commonly known as European mistletoe, is a hemi-parasitic plant of the Santalaceae family. The in vitro and in vivo effects of V. album differ, according to its host tree. However, little is known about the host-dependent phytochemical diversity in V. album. In this study, the metabolic profiles of V. album ssp. album from Malus domestica Bork., Quercus robur L., and Ulmus carpinifolia Gled were compared. Leaves, stems, and berries were collected in Switzerland, by the same procedure, in September 2016 and 2017. The methanolic extracts were analyzed by ultra-performance liquid chromatography, coupled to electrospray quadrupole time-of-flight mass spectrometry in positive ionization mode. The data were submitted to partial-least square discriminant analysis (PLS-DA) and the results showed that the V. album ssp. album samples were clustered into three groups, according to the three distinct host trees. Seven compounds, with high VIP scores (variable importance in projection), were responsible for this differentiation. The following four compounds were detected in both the harvest years: arginine, pipecolic acid or lysine, dimethoxycoumarin, and sinapyl alcohol, suggesting their use as host specific V. album biomarkers. The present work highlights the importance of standardized harvest and analytical procedures for the reproducibility of the chemical results of herbal materials.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM) |
UniBE Contributor: |
Baumgartner, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2223-7747 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Maurice Gisler |
Date Deposited: |
17 Nov 2021 07:22 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.3390/plants10081726 |
PubMed ID: |
34451771 |
Uncontrolled Keywords: |
Viscum album host tree metabolite fingerprinting mistletoe multivariate analysis |
BORIS DOI: |
10.48350/160595 |
URI: |
https://boris.unibe.ch/id/eprint/160595 |
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