Oesch, Lukas T.; Adamantidis, Antoine R. (2021). How REM sleep shapes hypothalamic computations for feeding behavior. Trends in neurosciences, 44(12), pp. 990-1003. Elsevier 10.1016/j.tins.2021.09.003
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The electrical activity of diverse brain cells is modulated across states of vigilance, namely wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. Enhanced activity of neuronal circuits during NREM sleep impacts on subsequent awake behaviors, yet the significance of their activation, or lack thereof, during REM sleep remains unclear. This review focuses on feeding-promoting cells in the lateral hypothalamus (LH) that express the vesicular GABA and glycine transporter (vgat) as a model to further understand the impact of REM sleep on neural encoding of goal-directed behavior. It emphasizes both spatial and temporal aspects of hypothalamic cell dynamics across awake behaviors and REM sleep, and discusses a role for REM sleep in brain plasticity underlying energy homeostasis and behavioral optimization.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Oesch, Lukas Till, Adamantidis, Antoine Roger |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1878-108X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
24 Nov 2021 08:56 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.1016/j.tins.2021.09.003 |
PubMed ID: |
34663506 |
Uncontrolled Keywords: |
feeding goal-directed behavior hypothalamus population coding sleep |
BORIS DOI: |
10.48350/160844 |
URI: |
https://boris.unibe.ch/id/eprint/160844 |
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