Larsen, Lotte Hardbo; Z'Graggen, Werner J; Bostock, Hugh; Tan, S Veronica; Buus, Niels Henrik; Tankisi, Hatice (2021). The role of potassium in muscle membrane dysfunction in end-stage renal disease. Clinical neurophysiology, 132(12), pp. 3125-3135. Elsevier 10.1016/j.clinph.2021.09.012
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OBJECTIVE
Uremic myopathy is a condition seen in end-stage renal disease (ESRD), characterized by muscle weakness and muscle fatigue, in which the pathophysiology is uncertain. The aim of this study was to assess the role of abnormal serum constituents in ESRD patients by relating them to the excitability properties of the tibialis anterior muscle, at rest and during electrically induced muscle activation, by recording muscle velocity recovery cycles (MVRC) and frequency ramp responses.
METHODS
Eighteen ESRD patients undergoing hemodialysis were evaluated by blood sample, MVRC, and frequency ramp (before and near the end of dialysis treatment), quantitative electromyography, and nerve conduction studies. Patients were compared to 24 control subjects.
RESULTS
In patients, muscle relative refractory period, early supernormality, late supernormality after 5 conditioning stimuli, and latency of the last of 15 and 30 frequency ramp pulses were strongly associated with potassium levels (p < 0.01), showing depolarization before and normalization in the end of hemodialysis.
CONCLUSIONS
In ESRD patients, the muscle membrane is depolarized, mainly due to hyperkalemia.
SIGNIFICANCE
Since normal muscle fatigue has been attributed to potassium-induced depolarization, it seems likely that this mechanism is also a major cause of the exaggerated muscle fatigue and weakness in ESRD patients.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Z'Graggen, Werner Josef |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1388-2457 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Nicole Söll |
Date Deposited: |
16 Nov 2021 16:51 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.1016/j.clinph.2021.09.012 |
PubMed ID: |
34740043 |
Uncontrolled Keywords: |
Electromyography End-stage renal disease Frequency ramp Hemodialysis Hyperkalemia Muscle velocity recovery cycles Uremic myopathy |
BORIS DOI: |
10.48350/160933 |
URI: |
https://boris.unibe.ch/id/eprint/160933 |
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