Bitzi, Lorena M; Lehnick, Dirk; Wilder-Smith, Einar (2021). Small fiber neuropathy: Swiss cohort characterization. Muscle & nerve, 64(3), pp. 293-300. John Wiley & Sons 10.1002/mus.27340
|
Text
Bitzi__2021__Small_fiber_neuropathy.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
INTRODUCTION/AIM
There is currently insufficient clinical and epidemiological data concerning small fiber neuropathy (SFN). This research analyzes data from medical records to determine epidemiology, demographics, clinical characteristics and etiology of SFN.
METHODS
This is a retrospective, observational study of sequential patients diagnosed with definite SFN (typical clinical features, normal nerve conduction studies, abnormal epidermal nerve fiber density) from the end of November 2016 to the middle of July 2019 at the Cantonal Hospital Lucerne, central Switzerland.
RESULTS
A total of 84 patients (64.3% female) with a mean age of 54.7 y were analyzed. Symptoms had been present in patients for an average of 4.8 y when entering the study. A length dependent clinical pattern was seen in 79.8%. All patients had sensory discomfort. Etiology could not be determined in 35.7% of patients, who were diagnosed with idiopathic SFN; 34.5% of patients had an apparently autoimmune SFN, followed by14.3% of patients with metabolic causes. The estimated incidence was at least 4.4 cases/100.000 inhabitants/y. The minimum prevalence was 131.5 cases/100.000 inhabitants.
DISCUSSION
This study indicates significant incidence and prevalence rates of SFN in Switzerland. SFN can vary greatly in its symptoms and severity. Extensive work-up resulted in two thirds of the patients being assigned an etiological association. The largest group of patients could not be etiologically defined, underlining the importance of further research on etiologic identification. We expect increased awareness of the developing field of SFN.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Wilder-Smith, Einar |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0148-639X |
Publisher: |
John Wiley & Sons |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
01 Dec 2021 10:50 |
Last Modified: |
05 Dec 2022 15:54 |
Publisher DOI: |
10.1002/mus.27340 |
PubMed ID: |
34075618 |
Uncontrolled Keywords: |
autoimmune neuropathy incidence prevalence neuropathic pain sensory and autonomic neuropathies small fiber neuropathy |
BORIS DOI: |
10.48350/161314 |
URI: |
https://boris.unibe.ch/id/eprint/161314 |
Actions (login required)
 |
Edit item |