Ripp, Isabelle; Wallenwein, Lara A; Wu, Qiong; Emch, Monica; Koch, Kathrin; Cumming, Paul; Yakushev, Igor (2021). Working memory task induced neural activation: A simultaneous PET/fMRI study. NeuroImage, 237, p. 118131. Elsevier 10.1016/j.neuroimage.2021.118131
|
Text
1-s2.0-S1053811921004080-main.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
PURPOSE
Positron emission tomography (PET) with [18F]fluorodeoxyglucose (FDG) is a powerful method for mapping cerebral glucose metabolism as a proxy of neural activity, assuming a steady-state during the recording interval. We asked if a clinical FDG-PET imaging protocol might also capture changes in neural activity associated with performance of a working memory (WM) task.
METHODS
To test this concept, we examined hybrid PET/MR data for FDG-PET and simultaneous functional magnetic resonance imaging (fMRI) in a sample of healthy volunteers. The PET image acquisition started 30 min after a bolus injection of approximately 100 MBq FDG, and the WM task was undertaken starting at approximately 60 min post-injection. We reconstructed FDG-PET sum images corresponding to baseline (44-60 min p.i.) and WM tasks (63- 71 min p.i.), each with intensity scaling to the corresponding global mean.
RESULTS
Compared to the baseline resting condition, relative FDG uptake increased during WM task performance in brain regions previously associated with WM. Furthermore, these metabolically active regions partly overlapped with the regions showing task-dependent increases in BOLD signal in simultaneous fMRI.
CONCLUSION
We find evidence for WM task-induced neural activation using a clinical FDG-PET imaging protocol. These findings encourage the development of dedicated protocols for tracking neural correlates of cognitive function.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine |
UniBE Contributor: |
Cumming, Paul |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1053-8119 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Daria Vogelsang |
Date Deposited: |
07 Jan 2022 10:02 |
Last Modified: |
05 Dec 2022 15:55 |
Publisher DOI: |
10.1016/j.neuroimage.2021.118131 |
PubMed ID: |
33951511 |
Uncontrolled Keywords: |
Cognition FDG PET Neuroimaging Positron emission tomography fMRI |
BORIS DOI: |
10.48350/161803 |
URI: |
https://boris.unibe.ch/id/eprint/161803 |
Actions (login required)
 |
Edit item |