Sharkey, Amy R; Sah, Bert-Ram; Withey, Samuel J; Bhuva, Shaheel; Neji, Radhouene; Jeljeli, Sami; Green, Adrian; Cook, Gary J R; Goh, Vicky (2021). Initial experience in staging primary oesophageal/gastro-oesophageal cancer with 18F-FDG PET/MRI. European journal of hybrid imaging, 5(1), p. 23. Springer 10.1186/s41824-021-00117-y
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BACKGROUND
18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) may improve cancer staging by combining sensitive cancer detection with high-contrast resolution and detail. We compared the diagnostic performance of 18F-FDG PET/MRI to 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for staging oesophageal/gastro-oesophageal cancer. Following ethical approval and informed consent, participants with newly diagnosed primary oesophageal/gastro-oesophageal cancer were enrolled. Exclusions included prior/concurrent malignancy. Following 324 ± 28 MBq 18F-FDG administration and 60-min uptake, PET/CT was performed, immediately followed by integrated PET/MRI from skull base to mid-thigh. PET/CT was interpreted by two dual-accredited nuclear medicine physicians and PET/MRI by a dual-accredited nuclear medicine physician/radiologist and cancer radiologist in consensus. Per-participant staging was compared with the tumour board consensus staging using the McNemar test, with statistical significance at 5%.
RESULTS
Out of 26 participants, 22 (20 males; mean ± SD age 68.8 ± 8.7 years) completed 18F-FDG PET/CT and PET/MRI. Compared to the tumour board, the primary tumour was staged concordantly in 55% (12/22) with PET/MRI and 36% (8/22) with PET/CT; the nodal stage was concordant in 45% (10/22) with PET/MRI and 50% (11/22) with PET/CT. There was no statistical difference in PET/CT and PET/MRI staging performance (p > 0.05, for T and N staging). The staging of distant metastases was concordant with the tumour board in 95% (21/22) with both PET/MRI and PET/CT. Of participants with distant metastatic disease, PET/MRI detected additional metastases in 30% (3/10).
CONCLUSION
In this preliminary study, compared to 18F-FDG PET/CT, 18F-FDG PET/MRI showed non-significant higher concordance with T-staging, but no difference with N or M-staging. Additional metastases detected by 18F-FDG PET/MRI may be of additive clinical value.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Sah, Bert-Ram |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2510-3636 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
13 Jan 2022 11:13 |
Last Modified: |
05 Dec 2022 15:56 |
Publisher DOI: |
10.1186/s41824-021-00117-y |
PubMed ID: |
34897589 |
Uncontrolled Keywords: |
Gastro-oesophageal cancer Oesophageal cancer PET/CT PET/MR |
BORIS DOI: |
10.48350/162373 |
URI: |
https://boris.unibe.ch/id/eprint/162373 |
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