Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies.

Minervini, Fabrizio; Boschetti, Laura; Gregor, Michael; Provencio, Mariano; Calvo, Virginia; Kestenholz, Peter B; Lampridis, Savvas; Patrini, Davide; Bertoglio, Pietro; Azenha, L Filipe; Sergi, Consolato M; Kocher, Gregor (2021). Thymic tumours: a single center surgical experience and literature review on the current diagnosis and management of thymic malignancies. Gland surgery, 10(11), pp. 3128-3140. AME Publishing 10.21037/gs-21-517

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Objective

This study aimed to provide an extensive overview of clinical and pathological findings along with various therapeutic options analyzing in addiction, retrospectively, the surgical outcomes of a single center cohort.

Background

Thymic neoplasms are rare thoracic tumors which commonly are located in the anterior mediastinum and are associated with a wide spectrum of clinical presentations. They may run an indolent course or could present a very aggressive biologic progression with infiltration of mediastinal structures and presence of distant metastases. The pathogenesis of these tumors is so far not completely clear. Several treatment modalities in a multidisciplinary setting have to be considered in order to provide the best treatment for patients affected by thymic tumors.

Methods

We conducted a retrospective cohort analysis of all patients who underwent surgery due to thymic tumor in a university hospital located in Switzerland (Bern University Hospital) and then we performed a narrative review of the English literature using PubMed, Embase, Cochrane Database of Systematic Reviews and Scopus.

Conclusions

Minimally invasive techniques play an important role in the treatment of thymic tumors. A careful patients selection in a multidisciplinary setting is mandatory in order to offer the best treatment for patients affected by thymic tumors.

Interest & Impact

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Citations

5 Citations in Web of Science ®
6 Citations in Scopus

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