Clinical benefit of left atrial appendage closure in octogenarians.

Mohrez, Yamen; Gloekler, Steffen; Schnupp, Steffen; Allakkis, Wasim; Liu, Xiao-Xia; Fuerholz, Monika; Brachmann, Johannes; Windecker, Stephan; Achenbach, Stephan; Meier, Bernhard; Kleinecke, Caroline (2021). Clinical benefit of left atrial appendage closure in octogenarians. Journal of geriatric cardiology : JGC, 18(11), pp. 886-896. Institute of Geriatric Cardiology of Chinese PLA 10.11909/j.issn.1671-5411.2021.11.003

Text Clinical_benefit_of_left_atrial_appendage_closure_in_octogenarians.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (4MB)

OBJECTIVES

Whether left atrial appendage closure (LAAC) in octogenarians yield similar net clinical benefit compared to younger patients, was the purpose of the present study.

METHODS

Two real-world LAAC registries, enrolling 744 consecutive Amplatzer and Watchman patients from 2009 to 2018, were retrospectively analyzed.

RESULTS

All events are reported per 100 patient-years. Two hundred and sixty one octogenarians and 483 non-octogenarians with a mean follow-up of 1.7 ± 1.3 and 2.3 ± 1.6 years, and a total of 1,502 patient-years were included. Octogenarians had a higher risk for stroke (CHA2DS2-VASc score: 5.2 ± 1.2 vs. 4.3 ± 1.7, P < 0.0001) and bleeding (HAS-BLED score: 3.3 ± 0.8 vs. 3.1 ± 1.1, P = 0.001). The combined safety endpoint of major periprocedural complications and major bleeding events at follow-up was comparable (30/446, 6.7% vs. 47/1056, 4.4%; hazard ratio [HR] = 1.2; 95% confidence interval [CI]: 0.73-1.98;P = 0.48) between the groups. The efficacy endpoint of all-cause stroke, systemic embolism, and cardiovascular/unexplained death occurred more often in octogenarians (61/446, 13.7% vs. 80/1056, 7.6%; HR = 7.0; 95% CI: 4.53-10.93;P < 0.0001). Overall, octogenarians had a lower net clinical benefit, i.e., the composite of all above mentioned hazards, from LAAC compared to younger patients (82/446, 18.4% vs. 116/1056, 11.0%; HR = 4.6; 95% CI: 3.11-7.0;P < 0.0001). Compared to the anticipated stroke rate, the observed rate decreased by 41% in octogenarians and 53% in non-octogenarians. The observed bleeding rate was reduced by 10% octogenarians and 41% non-octogenarians.

CONCLUSIONS

LAAC can be performed with similar safety in octogenarians as compared to younger patients. On the long-term, it both reduces stroke and bleeding events, although to a lesser extent than in non-octogenarians.

Interest & Impact

Downloads

2 since deposited on 29 Dec 2021
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item