Gasparri, Maria Luisa; Kuehn, Thorsten; Ruscito, Ilary; Zuber, Veronica; Di Micco, Rosa; Galiano, Ilaria; Navarro Quinones, Siobana C; Santurro, Letizia; Di Vittorio, Francesca; Meani, Francesco; Bassi, Valerio; Ditsch, Nina; Mueller, Michael D; Bellati, Filippo; Caserta, Donatella; Papadia, Andrea; Gentilini, Oreste D (2021). Fibrin Sealants and Axillary Lymphatic Morbidity: A Systematic Review and Meta-Analysis of 23 Clinical Randomized Trials. Cancers, 13(9) MDPI AG 10.3390/cancers13092056
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BACKGROUND
use of fibrin sealants following pelvic, paraaortic, and inguinal lymphadenectomy may reduce lymphatic morbidity. The aim of this meta-analysis is to evaluate if this finding applies to the axillary lymphadenectomy.
METHODS
randomized trials evaluating the efficacy of fibrin sealants in reducing axillary lymphatic complications were included. Lymphocele, drainage output, surgical-site complications, and hospital stay were considered as outcomes.
RESULTS
twenty-three randomized studies, including patients undergoing axillary lymphadenectomy for breast cancer, melanoma, and Hodgkin's disease, were included. Fibrin sealants did not affect axillary lymphocele incidence nor the surgical site complications. Drainage output, days with drainage, and hospital stay were reduced when fibrin sealants were applied (p < 0.0001, p < 0.005, p = 0.008).
CONCLUSION
fibrin sealants after axillary dissection reduce the total axillary drainage output, the duration of drainage, and the hospital stay. No effects on the incidence of postoperative lymphocele and surgical site complications rate are found.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Mueller, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
25 Jan 2022 17:02 |
Last Modified: |
05 Dec 2022 16:00 |
Publisher DOI: |
10.3390/cancers13092056 |
PubMed ID: |
33923153 |
Uncontrolled Keywords: |
axillary lymphadenectomy breast cancer fibrin sealant lymphatic morbidity lymphocele |
BORIS DOI: |
10.48350/163604 |
URI: |
https://boris.unibe.ch/id/eprint/163604 |
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