Ramanauskaite, Egle; Moraschini, Vittorio; Machiulskiene, Vita; Sculean, Anton (2021). Clinical efficacy of single and multiple applications of antimicrobial photodynamic therapy in periodontal maintenance: A systematic review and network meta-analysis. Photodiagnosis and photodynamic therapy, 36, p. 102435. Elsevier 10.1016/j.pdpdt.2021.102435
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BACKGROUND
At present the clinical efficacy of single (S) versus multiple (M) applications of antimicrobial photodynamic therapy (aPDT) is controversially discussed.
AIM
To systematically evaluate the clinical efficacy of adjunctive S and M applications of aPDT to subgingival debridement (SD) in the treatment of residual periodontal pockets.
METHODS
An electronic search was carried out for randomized controlled clinical trials (RCTs) reporting on SD with the adjunctive use of S- or M-aPDT applications.
RESULTS
Statistically significantly higher improvement in bleeding on probing (BOP) and probing depth (PD) reduction was found for SD + S-aPDT versus SD, with Mean difference (MD) = -16.8 (95% CI: -30.7 to -2.91; p = 0.02) and 0.4, (95% CI: 0.02 to 0.78, p = 0.04), respectively. Regarding BOP, there was also a statistically significant difference when SD + M-aPDT was compared with SD alone, with a MD of -5.13 (95% CI: -7.20 to -3.07; p < 0.00001). For all parameters, SD + S-aPDT demonstrated the best treatment ranking of probability results, followed by SD + M-aPDT and SD alone.
CONCLUSIONS
Within their limits, the present data indicate that in periodontal patients enrolled in maintenance: a) single and multiple adjunctive applications of aPDT following SD resulted in statistically significant BOP reduction compared to SD alone, and b) repeated applications of aPDT did not seem to result in superior outcomes compared to single applications.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1873-1597 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Doris Burri |
Date Deposited: |
26 Jan 2022 11:19 |
Last Modified: |
05 Dec 2022 16:00 |
Publisher DOI: |
10.1016/j.pdpdt.2021.102435 |
PubMed ID: |
34245916 |
Uncontrolled Keywords: |
Periodontitis Photodynamic therapy Systematic Review periodontal maintenance residual pockets |
BORIS DOI: |
10.48350/163694 |
URI: |
https://boris.unibe.ch/id/eprint/163694 |
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