Shirakata, Yoshinori; Nakamura, Toshiaki; Kawakami, Yoshiko; Imafuji, Takatomo; Shinohara, Yukiya; Noguchi, Kazuyuki; Sculean, Anton (2021). Healing of buccal gingival recessions following treatment with coronally advanced flap alone or combined with a cross-linked hyaluronic acid gel. An experimental study in dogs. Journal of clinical periodontology, 48(4), pp. 570-580. Wiley 10.1111/jcpe.13433
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J_Clinic_Periodontology_-_2021_-_Shirakata_-_Healing_of_buccal_gingival_recessions_following_treatment_with_coronally.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (2MB) | Preview |
AIM
To clinically and histologically evaluate in dogs the healing of gingival recessions treated with coronally advanced flap (CAF) with or without cross-linked hyaluronic acid (HA).
MATERIALS AND METHODS
Gingival recession defects were surgically created on the vestibular side of both maxillary canines in 8 dogs. After 8 weeks of plaque accumulation, the 16 chronic defects were randomly treated with either CAF alone or CAF and HA-gel (CAF/HA). Clinical and histological outcomes were evaluated at 10 weeks post-surgically.
RESULTS
Compared to baseline, the clinical measurements at 10 weeks revealed a statistically significant decrease in gingival recession for both CAF (p < 0.01) and CAF/HA (p < 0.001) groups. Statistically significant differences were found in clinical attachment level (p < 0.05) and width of gingival recession (p < 0.01) favouring the CAF/HA group. Bone formation was statistically significantly greater in the CAF/HA group than in the CAF group (1.84 ± 1.16 mm vs., 0.72 ± 0.62 mm, respectively, p < 0.05). Formation of cementum and connective tissue attachment were statistically significantly higher in the CAF/HA group compared with the CAF group (i.e. 4.31 ± 1.78 mm versus 2.40 ± 1.35 mm and 1.69 ± 0.98 mm versus 0.74 ± 0.68 mm, respectively (p < 0.05)).
CONCLUSIONS
The present data have for the first time provided histologic evidence for periodontal regeneration of gingival recession defects following treatment with CAF and HA.
CLINICAL RELEVANCE
The use of HA in conjunction with CAF may represent a novel modality for treating gingival recession defects.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology |
UniBE Contributor: |
Sculean, Anton |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1600-051X |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Doris Burri |
Date Deposited: |
27 Jan 2022 11:55 |
Last Modified: |
05 Dec 2022 16:01 |
Publisher DOI: |
10.1111/jcpe.13433 |
PubMed ID: |
33513277 |
Uncontrolled Keywords: |
coronally advanced flap gingival recession histological investigation hyaluronic acid periodontal regeneration root coverage |
BORIS DOI: |
10.48350/163825 |
URI: |
https://boris.unibe.ch/id/eprint/163825 |
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