Seven-year efficacy and safety outcomes of Bulkamid for the treatment of stress urinary incontinence.

Brosche, Torsten; Kuhn, Annette; Lobodasch, Kurt; Sokol, Eric R (2021). Seven-year efficacy and safety outcomes of Bulkamid for the treatment of stress urinary incontinence. Neurourology and urodynamics, 40(1), pp. 502-508. Wiley 10.1002/nau.24589

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AIMS

Bulking agents are a minimally invasive treatment option for women with stress urinary incontinence (SUI) or stress-predominant mixed urinary incontinence (MUI). The aim of this study was to evaluate long-term efficacy and safety following treatment with Bulkamid as a primary procedure for SUI or stress-predominant MUI.

METHODS

This was an Institutional Review Board-approved single-center retrospective study of female patients with SUI or stress-predominant MUI who had undergone injection with Bulkamid since 2005 and had completed 7 years of follow up. The primary endpoint was patient satisfaction measured on a four-point scale as cured, improved, unchanged, or worse. Secondary outcomes included the number of incontinence pads used, International Consultation on Incontinence Questionnaire-Short Form (ICIQ-UI SF) scores, Visual Analog Scale Quality of Life (VAS QoL), reinjection rates, and perioperative and postoperative complications.

RESULTS

A total of 1,200 patients were treated with Bulkamid since 2005 and of these, 388 (32.3%) had completed 7 years of follow-up. A total of 67.1% of the patients reported feeling cured or improved if Bulkamid was a primary procedure, 11.1% reported no change, and 2.3% reported worsening of incontinence. A total of 19.5% of patients received a subsequent other incontinence procedure. The ICIQ-UI SF was reduced by 8.6 points. VAS QoL improved by a mean of 4.3 points. Postoperative complications were transient. Prolonged bladder emptying time was reported in 15.3% of patients and urinary tract infection in 3.5%.

CONCLUSIONS

Bulkamid injections are an effective and safe first-line treatment option for women with SUI or stress-predominant MUI providing durable outcomes at 7 years.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Kuhn, Annette

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1520-6777

Publisher:

Wiley

Language:

English

Submitter:

Monika Zehr

Date Deposited:

02 Feb 2022 14:33

Last Modified:

19 May 2024 23:52

Publisher DOI:

10.1002/nau.24589

PubMed ID:

33410544

Uncontrolled Keywords:

Bulkamid bulking agents long-term follow-up mixed urinary incontinence stress urinary incontinence

BORIS DOI:

10.48350/163858

URI:

https://boris.unibe.ch/id/eprint/163858

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