Kühnisch, Jan; Janjic Rankovic, Mila; Kapor, Svetlana; Schüler, Ina; Krause, Felix; Michou, Stavroula; Ekstrand, Kim; Eggmann, Florin; Neuhaus, Klaus W; Lussi, Adrian; Huysmans, Marie-Charlotte (2021). Identifying and Avoiding Risk of Bias in Caries Diagnostic Studies. Journal of clinical medicine, 10(15) MDPI 10.3390/jcm10153223
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Caries diagnostic studies differ with respect to their design, included patients/tooth samples, use of diagnostic and reference methods, calibration, blinding and data reporting. Such heterogeneity makes comparisons between studies difficult and could represent a substantial risk of bias (RoB) when it is not identified. Therefore, the present report aims to describe the development and background of a RoB assessment tool for caries diagnostic studies. The expert group developed and agreed to use a RoB assessment tool during three workshops. Here, existing instruments (e.g., QUADAS 2 and the Joanna Briggs Institute Reviewers' Manual) influenced the hierarchy and phrasing of the signalling questions that were adapted to the specific dental purpose. The tailored RoB assessment tool that was created consists of 16 signalling questions that are organized in four domains. This tool considers the selection/spectrum bias (1), the bias of the index (2) and reference tests (3), and the bias of the study flow and data analysis (4) and can be downloaded from the journal website. This paper explores possible sources of heterogeneity and bias in caries diagnostic studies and summarizes the relevant methodological aspects.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Research |
UniBE Contributor: |
Lussi, Adrian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Doris Burri |
Date Deposited: |
31 Jan 2022 10:37 |
Last Modified: |
05 Dec 2022 16:02 |
Publisher DOI: |
10.3390/jcm10153223 |
PubMed ID: |
34362007 |
Uncontrolled Keywords: |
caries assessment caries detection caries diagnostics caries monitoring clinical studies laboratory studies methodology reference standard |
BORIS DOI: |
10.48350/163997 |
URI: |
https://boris.unibe.ch/id/eprint/163997 |
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