Bürgler, Christina; Weibel, Lisa; Schwieger-Briel, Agnes; Knöpfel, Nicole; Luchsinger, Isabelle; Theiler, Martin (2021). Gianotti-Crosti syndrome-like reaction to molluscum contagiosum-Clinical characteristics and response to treatment. Journal of the German Society of Dermatology, 19(12), pp. 1746-1751. Wiley 10.1111/ddg.14608
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J_Deutsche_Derma_Gesell_-_2021_-_B_rgler_-_Gianotti_Crosti_syndrome_like_reaction_to_molluscum_contagiosum_Clinical.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (863kB) | Preview |
BACKGROUND AND OBJECTIVES
Molluscum contagiosum (MC) is a common viral infection. Hypersensitivity reactions reminiscent of Gianotti-Crosti syndrome, termed Gianotti-Crosti syndrome-like reaction (GCLR), have been reported in a subset of patients. We report a series of patients with GCLR, better delineating its clinical presentation and course.
PATIENTS AND METHODS
Retrospective chart review of all children presenting with GCLR at our Pediatric Skin Center between 2015 and 2020.
RESULTS
26 children (14 boys) with a median age of 6.5 (3-11.3) years were included. GCLR involved the extensor surfaces of the extremities in all patients. More widespread eruptions also affected the trunk and face in 7 (27 %) and 6 (23 %) children respectively. Involvement of the skin overlying the Achilles tendons was a new finding in 4 (15 %) children. Itch was the predominant symptom in 20 (77 %) patients. The rash responded to topical and/or systemic corticosteroids and resolved within four weeks. GCLR was followed by clearance of MC in all patients within 9 (4-24) weeks.
CONCLUSIONS
GCLR is a characteristic acute, wide-spread, pruritic papular eruption, which often leads to emergency consultations and anxiety in affected patients. GCLR responds well to corticosteroid treatment, has a benign course, and heralds the healing of MC.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Bürgler, Christina |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1610-0387 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Andrea Studer-Gauch |
Date Deposited: |
01 Feb 2022 11:51 |
Last Modified: |
05 Dec 2022 16:03 |
Publisher DOI: |
10.1111/ddg.14608 |
PubMed ID: |
34761533 |
Uncontrolled Keywords: |
Gianotti-Crosti syndrome-like reaction molluscum contagiosum |
BORIS DOI: |
10.48350/164278 |
URI: |
https://boris.unibe.ch/id/eprint/164278 |
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