Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis.

Pichi, Francesco; Carreño, Ester; Pavesio, Carlos; Denniston, Alastair K; Grewal, Dilraj S; Deak, Gabor; Khairallah, Moncef; Ruiz-Cruz, Matilde; de Oliveira Dias, Joao Rafael; Adan, Alfredo; Burke, Tomas; Invernizzi, Alessandro; Schlaen, Ariel; Tian, Meng; Agarwal, Aniruddha Kishandutt; Tucker, William R; Sen, H Nida; Lin, Phoebe; Lim, Lyndell L; Pepple, Kathryn L; ... (2023). Consensus-based recommendations for optical coherence tomography angiography reporting in uveitis. The British journal of ophthalmology, 107(7), pp. 959-965. BMJ Publishing Group 10.1136/bjophthalmol-2021-320021

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BACKGROUND/AIMS

To establish a consensus in the nomenclature for reporting optical coherence tomography angiography (OCTA findings in uveitis.

METHODS

The modified Delphi process consisted of two rounds of electronic questionnaires, followed by a face-to-face meeting conducted virtually. Twenty-one items were included for discussion. The three main areas of discussion were: wide field OCTA (WF-OCTA), nomenclature of OCTA findings and OCTA signal attenuation assessment and measurement. Seventeen specialists in uveitis and retinal imaging were selected by the executive committee to constitute the OCTA nomenclature in Uveitis Delphi Study Group. The study endpoint was defined by the degree of consensus for each question: 'strong consensus' was defined as >90% agreement, 'consensus' as 85%-90% and 'near consensus' as >80% but <85%.

RESULTS

There was a strong consensus to apply the term 'wide field' to OCTA images measuring over 70° of field of view, to use the terms 'flow void' and 'non-detectable flow signal' to describe abnormal OCTA flow signal secondary to vessels displacement and slow flow respectively, to use the terms 'loose' and 'dense' to describe the appearance of inflammatory choroidal neovascularisation, and to use the percentage of flow signal decrease to measure OCTA ischaemia with a threshold greater than or equal to 30% as a 'large area'.

CONCLUSIONS

This study sets up consensus recommendations for reporting OCTA findings in uveitis by an expert panel, which may prove suitable for use in routine clinical care and clinical trials.

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