Schaller, Johann; Gerber, Simon S (2011). The plasmin-antiplasmin system: structural and functional aspects. Cellular and molecular life sciences, 68(5), pp. 785-801. Basel: SP Birkhäuser Verlag Basel 10.1007/s00018-010-0566-5
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The plasmin-antiplasmin system plays a key role in blood coagulation and fibrinolysis. Plasmin and (2)-antiplasmin are primarily responsible for a controlled and regulated dissolution of the fibrin polymers into soluble fragments. However, besides plasmin(ogen) and (2)-antiplasmin the system contains a series of specific activators and inhibitors. The main physiological activators of plasminogen are tissue-type plasminogen activator, which is mainly involved in the dissolution of the fibrin polymers by plasmin, and urokinase-type plasminogen activator, which is primarily responsible for the generation of plasmin activity in the intercellular space. Both activators are multidomain serine proteases. Besides the main physiological inhibitor (2)-antiplasmin, the plasmin-antiplasmin system is also regulated by the general protease inhibitor (2)-macroglobulin, a member of the protease inhibitor I39 family. The activity of the plasminogen activators is primarily regulated by the plasminogen activator inhibitors 1 and 2, members of the serine protease inhibitor superfamily.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology and Immunology |
UniBE Contributor: |
Schaller, Johann, Gerber, Simon (B) |
ISSN: |
1420-682X |
Publisher: |
SP Birkhäuser Verlag Basel |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:10 |
Last Modified: |
29 Mar 2023 23:32 |
Publisher DOI: |
10.1007/s00018-010-0566-5 |
PubMed ID: |
21136135 |
Web of Science ID: |
000287243400004 |
BORIS DOI: |
10.7892/boris.1656 |
URI: |
https://boris.unibe.ch/id/eprint/1656 (FactScience: 203508) |
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