C3-targeted therapy in periodontal disease: moving closer to the clinic.

Hajishengallis, George; Hasturk, Hatice; Lambris, John D (2021). C3-targeted therapy in periodontal disease: moving closer to the clinic. Trends in immunology, 42(10), pp. 856-864. Elsevier Current Trends 10.1016/j.it.2021.08.001

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Complement plays a key role in immunosurveillance and homeostasis. When dysregulated or overactivated, complement can become a pathological effector, as seen in several inflammatory disorders, including periodontal disease. Recently, clinical correlative studies and preclinical mechanistic investigations have collectively demonstrated that complement is hyperactivated during periodontitis and that targeting its central component (C3) provides therapeutic benefit in nonhuman primates (NHPs). The preclinical efficacy of a C3-targeted drug candidate combined with excellent safety and pharmacokinetic profiles supported its use in a recent Phase IIa clinical study in which C3 inhibition resolved gingival inflammation in patients with periodontal disease. We posit that C3-targeted intervention might represent a novel and transformative host-modulation therapy meriting further investigation in Phase III clinical trials for the treatment of periodontitis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1471-4906

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Doris Burri

Date Deposited:

08 Mar 2022 15:59

Last Modified:

08 Mar 2022 15:59

Publisher DOI:

10.1016/j.it.2021.08.001

PubMed ID:

34483038

Additional Information:

Contributing author: Anton Sculean

BORIS DOI:

10.48350/165721

URI:

https://boris.unibe.ch/id/eprint/165721

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