Immunotoxic effects of metal-based nanoparticles in fish and bivalves.

Rastgar, Sara; Alijani Ardeshir, Rashid; Segner, Helmut; Tyler, Charles R; J G M Peijnenburg, Willie; Wang, Youji; Salati, Amir Parviz; Movahedinia, Abdolali (2022). Immunotoxic effects of metal-based nanoparticles in fish and bivalves. Nanotoxicology, 16(1), pp. 88-113. Taylor & Francis 10.1080/17435390.2022.2041756

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There is a global research interest in metal nanoparticles (MNPs) due to their diverse applications, rapidly increasing use, and increased presence in the aquatic environment. Currently, most MNPs in the environment are at levels unlikely to cause overt toxicity. Sub-lethal effects that MNPs may induce, notable immunotoxicity, could however have significant health implications. Thus, deciphering the immunological interactions of MNPs with aquatic organisms constitutes a much-needed area of research. In this article, we critically assess the evidence for immunotoxic effects of MNPs in bivalves and fish, as key wildlife sentinels with widely differing ecological niches that are used as models in ecotoxicology. The first part of this review details the properties, fate, and fundamental physicochemical behavior of MNPs in the aquatic ecosystem. We then consider the toxicokinetics of MNP uptake, accumulation, and deposition in fish and bivalves. The main body of the review then focuses on immune reactions in response to MNPs exposure in bivalves and fish illustrating their immunotoxic potential. Finally, we identify major knowledge gaps in our current understanding of the implications of MNPs exposure for immunological functions and the associated health consequences for bivalves and fish, as well as the general lessons learned on the immunotoxic properties of the emerging class of nanoparticulate contaminants in fish and bivalves.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute for Fish and Wildlife Health (FIWI)
UniBE Contributor:	Segner, Helmut
Subjects:	600 Technology > 630 Agriculture
ISSN:	1743-5404
Publisher:	Taylor & Francis
Language:	English
Submitter:	Pubmed Import
Date Deposited:	25 Feb 2022 09:39
Last Modified:	05 Dec 2022 16:10
Publisher DOI:	10.1080/17435390.2022.2041756
PubMed ID:	35201945
Uncontrolled Keywords:	Metal nanoparticles bivalves fish immunotoxicity
URI:	https://boris.unibe.ch/id/eprint/166026