Bracher, Ava Insa; Vig, Navin; Burkhard, John-Patrik; Schaller, Benoît; Schlittler, Fabian (2021). The application of platelet rich fibrin in patients presenting with osteonecrosis of the jaw: A systematic literature review. Advances in oral and maxillofacial surgery, 2, p. 100076. Elsevier 10.1016/j.adoms.2021.100076
|
Text
1-s2.0-S2667147621000637-main.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (448kB) | Preview |
The aim of this systematic literature review was to summarise the available evidence regarding the administration
of platelet rich fibrin (PRF) in patients diagnosed with osteonecrosis of the jaw (ONJ). A PRISMA-conform sys-
tematic literature review was conducted using a PICO-defined search strategy. MEDLINE was accessed and hits
published before February 2020 were reviewed. All studies reporting on intraoperative administration of PRF into
an osseous defect in patients presenting with ONJ were included. Eligibility of the studies was assessed by two
independent reviewers according to prespecified criteria. Sixteen studies described the application of PRF for
treatment of ONJ in 166 patients. Follow-up periods ranged from 30 to 1560 days. There was large heterogeneity
regarding patient details and perioperative management. The only randomised controlled study (RCT) included
suggested modest superiority in early recovery, infection rate and reported pain. No adverse events related to PRF
were reported in any of the studies. The evidence regarding relative merits of PRF application versus standard of
care in patients with ONJ is low. Current evidence is limited by small, non-consecutive patient samples and lack of
a randomised control group. Because some observational reports and one RCT suggested improvements of early
recovery, further studies are needed
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery |
UniBE Contributor: |
Burkhard, John Patrik Matthias, Schaller, Benoît, Schlittler, Fabian |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2667-1476 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Caroline Dominique Zürcher |
Date Deposited: |
11 Mar 2022 13:33 |
Last Modified: |
05 Dec 2022 16:14 |
Publisher DOI: |
10.1016/j.adoms.2021.100076 |
BORIS DOI: |
10.48350/167185 |
URI: |
https://boris.unibe.ch/id/eprint/167185 |
Actions (login required)
 |
Edit item |