Betting, Adeline; Schweighauser, Ariane; Francey, Thierry (2022). Diagnostic value of reticulocyte indices for the assessment of the iron status of cats with chronic kidney disease. Journal of veterinary internal medicine, 36(2), pp. 619-628. Wiley 10.1111/jvim.16367
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JVIM_2022_BETTING_-_Diagnostic_value_of_reticulocyte_indices_for_the_assessment_of_the_iron_deficiency.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
BACKGROUND
Reticulocyte indices have been suggested as alternatives to transferrin saturation (TSAT) for iron status assessment in humans and dogs but they have not been evaluated thoroughly in cats.
OBJECTIVES
To assess the value of the reticulocyte indices for the diagnosis of iron deficiency in cats with chronic kidney disease (CKD) and chronic hematuria associated with subcutaneous ureteral bypasses (SUBs).
ANIMALS
Sixty-four cats: 16 healthy, 14 CKD without SUB, and 34 CKD with SUB.
METHODS
Prospective observational cross-sectional study of cats presented for routine nephrology visits. Primary outcomes included assessment of the diagnostic values of erythrocyte indices (mean corpuscular volume, hemoglobin, and hemoglobin concentration: MCV, MCH, and MCHC) and reticulocyte indices (mean corpuscular volume, MCVr; corpuscular hemoglobin, CHr), using TSAT as reference.
RESULTS
Iron deficiency was diagnosed in 9/64 cats (14%). A receiver-operating characteristic curve analysis yielded a moderate discriminatory value for CHr in this diagnosis: area under the curve [AUC] = .75 (95% confidence interval, 0.48-0.89); P = .006; sensitivity 67%, specificity 82% for a cutoff of 15.9 pg. This compared favorably to MCVr (AUC = .63; P = .29), MCV (AUC = .58; P = .45), MCH (AUC = .64; P = .19), and MCHC (AUC = .7; P = .03).
CONCLUSION AND CLINICAL IMPORTANCE
CHr added moderate value to the diagnosis of iron deficiency in cats with CKD.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) 05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Internal Medicine |
UniBE Contributor: |
Betting, Adeline, Schweighauser, Ariane, Francey, Thierry |
Subjects: |
600 Technology > 630 Agriculture 600 Technology > 610 Medicine & health |
ISSN: |
1939-1676 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Thierry Francey-Spicher |
Date Deposited: |
15 Mar 2022 19:12 |
Last Modified: |
05 Dec 2022 16:15 |
Publisher DOI: |
10.1111/jvim.16367 |
Related URLs: |
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PubMed ID: |
35090061 |
Uncontrolled Keywords: |
CHr MCVr iron deficiency serum iron concentration transferrin saturation |
BORIS DOI: |
10.48350/167337 |
URI: |
https://boris.unibe.ch/id/eprint/167337 |
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