Henes, M; Henes, JC; Schmalzing, M; von Wolff, M; Hübner, S; Kötter, I; Lawrenz, B (2012). Fertilitätsportektion bei rheumatischen Erkranungen. Gynäkologische Endokrinologie, 10(2), pp. 105-109. Heidelberg: Springer-Medizin-Verlag 10.1007/s10304-011-0457-3
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Cytotoxic therapy which can harm ovarian function is not only used for malignant diseases but also for severe autoimmune diseases (AID) using mainly the immunosuppressive agent cyclophosphamide. Young women during childbearing age are frequently affected by AID. Due to the significantly improved long-term survival of these patients, preservation of ovarian function is a very important issue.
Disease-specific risks must be taken into consideration when counselling patients with AID for fertility preservation. Systemic lupus erythematosus (SLE) is one of the more common forms of AID and the only AID with existing data on fertility preservation. Therefore the available techniques will be discussed on the basis of SLE.
Gonadotropin releasing hormone (GnRH) analogue treatment during cyclophosphamide therapy has been shown to be effective in patients with AID and can be recommended in almost all situations. Cryopreservation of ovarian tissue is still an experimental approach but seems to be very promising. The risk of the necessary laparoscopic surgery and the delay are justifiable. A stimulation therapy for cryopreservation of oocytes has the risk of an exacerbation of the underlying disease and of thromboembolic complications. Therefore this option should only be recommended in isolated cases and under close monitoring of disease activity by an interdisciplinary team of gynecologists and rheumatologists. Treatment with GnRH analogues and cryopreservation of ovarian tissue seems to be a reasonable combination.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
von Wolff, Michael |
ISSN: |
1610-2894 |
Publisher: |
Springer-Medizin-Verlag |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:41 |
Last Modified: |
05 Dec 2022 14:12 |
Publisher DOI: |
10.1007/s10304-011-0457-3 |
BORIS DOI: |
10.48350/16829 |
URI: |
https://boris.unibe.ch/id/eprint/16829 (FactScience: 224529) |
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