Damme, Katherine S F; Park, Jadyn S; Vargas, Teresa; Walther, Sebastian; Shankman, Stewart A; Mittal, Vijay A (2022). Motor abnormalities, depression risk, and clinical course in adolescence. Biological psychiatry global open science, 2(1), pp. 61-69. Elsevier 10.1016/j.bpsgos.2021.06.011
|
Text
1-s2.0-S2667174321000574-main.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (480kB) | Preview |
Background
Motor abnormalities, such as psychomotor agitation and retardation, are widely recognized as core features of depression. However, it is not currently known if motor abnormalities connote risk for depression.
Methods
Using data from the Adolescent Brain Cognitive Development (ABCD) Study, a nationally representative sample of youth (n=10,835, 9-11 years old), the present paper examines whether motor abnormalities are associated with (a) depression symptoms in early adolescence, (b) familial risk for depression (familial risk loading), and (c) future depression symptoms. Motor abnormalities measures included traditional (DSM) motor signs such as psychomotor agitation and retardation as well as other motor domains such as developmental motor delays and dyscoordination.
Results
Traditional motor abnormalities were less prevalent (agitation=3.2%, retardation=0.3%) than non-traditional domains (delays=13.79%, coordination=35.5%) among adolescents. Motor dysfunction was associated with depression symptoms (Cohen's ds=0.02 to 0.12). Familial risk for depression was related to motor abnormalities (Cohen's ds=0.08 to 0.27), with the exception of motor retardation. Family vulnerability varied in sensitivity to depression risk (e.g., retardation: .53%; dyscoordination: 32.05%). Baseline endorsement of motor abnormalities predicted future depression symptoms at one-year follow-up.
Conclusions
These findings suggest that motor signs reflect a novel, promising future direction for examining vulnerability to depression risk in early adolescence.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy |
UniBE Contributor: |
Walther, Sebastian |
ISSN: |
2667-1743 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
19 Apr 2022 09:23 |
Last Modified: |
05 Dec 2022 16:18 |
Publisher DOI: |
10.1016/j.bpsgos.2021.06.011 |
PubMed ID: |
35419552 |
BORIS DOI: |
10.48350/169330 |
URI: |
https://boris.unibe.ch/id/eprint/169330 |
Actions (login required)
 |
Edit item |