Han, Ling; Guo, Meiliang; Wang, Bing; Meng, Qinqin; Zhu, Jie; Huang, Qiong; Zhang, Zhenghua; Fang, Xu; Yang, Ke; Wu, Siyuan; Zheng, Zhizhong; Yawalkar, Nikhil; Deng, Hui; Yan, Kexiang (2022). Sex-differential downregulation of methotrexate on plasma viscosity and whole blood viscosity in psoriasis. Clinical hemorheology and microcirculation, 81(4), pp. 305-314. IOS Press 10.3233/CH-211343
Full text not available from this repository.BACKGROUND
Psoriasis is associated with an increased risk for cardiovascular disease (CVD). Methotrexate (MTX) is often used as a first-line system therapy and there is a need to determine its effect on whole blood viscosity (WBV) and plasma viscosity (PV) in psoriasis.METHODSA prospective, single-center, interventional study with a total of 111 psoriatic patients who received MTX therapy from October 22, 2018, to December 28, 2019, and 111 age- and sex-matched healthy controls. Changes in WBV, PV, blood counts, liver and renal function were evaluated.RESULTSPsoriatic patients had significantly higher levels of WBV and relative viscosity (RV) at low shear rate (LSR), erythrocyte aggregation index (EAI), and PV than sex and age-matched healthy controls. PV was positively correlated with erythrocyte sedimentation rate (ESR), ESR was positively correlated with high sensitive C-reactive protein (hCRP). But only hCRP was positively associated with psoriasis area severity index (PASI) score. MTX significantly decreased the levels of PV, ESR, hCRP, and blood pressure (BP) in male patients, and the level of WBV in female patients.
CONCLUSION
Sex-specific downregulation of MTX on WBV, PV, hCRP, and BP, indicating that the effect of MTX on the risk of cardiovascular disease was related with sex.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Yawalkar, Nikhil |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1386-0291 |
Publisher: |
IOS Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Apr 2022 13:39 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.3233/CH-211343 |
PubMed ID: |
35466929 |
Uncontrolled Keywords: |
Methotrexate erythrocyte aggregation index plasma viscosity psoriasis whole blood viscosity |
URI: |
https://boris.unibe.ch/id/eprint/169513 |
Actions (login required)
 |
Edit item |