De, Soumasree; Mühlemann, Oliver (2022). A comprehensive coverage insurance for cells: revealing links between ribosome collisions, stress responses and mRNA surveillance. RNA biology, 19(1), pp. 609-621. Taylor and Francis 10.1080/15476286.2022.2065116
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A_comprehensive_coverage_insurance_for_cells_revealing_links_between_ribosome_collisions_stress_responses_and_mRNA_surveillance.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (2MB) | Preview |
Cells of metazoans respond to internal and external stressors by activating stress response pathways that aim for re-establishing cellular homoeostasis or, if this cannot be achieved, triggering programmed cell death. Problems during translation, arising from defective mRNAs, tRNAs, ribosomes or protein misfolding, can activate stress response pathways as well as mRNA surveillance and ribosome quality control programs. Recently, ribosome collisions have emerged as a central signal for translational stress and shown to elicit different stress responses. Here, we review our current knowledge about the intricate mutual connections between ribosome collisions, stress response pathways and mRNA surveillance. A central factor connecting the sensing of collided ribosomes with degradation of the nascent polypeptides, dissociation of the stalled ribosomes and degradation of the mRNA by no-go or non-stop decay is the E3-ligase ZNF598. We tested whether ZNF598 also plays a role in nonsense-mediated mRNA decay (NMD) but found that it is dispensable for this translation termination-associated mRNA surveillance pathway, which in combination with other recent data argues against stable ribosome stalling at termination codons being the NMD-triggering signal.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
De, Soumasree, Mühlemann, Oliver |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1555-8584 |
Publisher: |
Taylor and Francis |
Language: |
English |
Submitter: |
Christina Schüpbach |
Date Deposited: |
02 May 2022 17:06 |
Last Modified: |
05 Dec 2022 16:19 |
Publisher DOI: |
10.1080/15476286.2022.2065116 |
PubMed ID: |
35491909 |
BORIS DOI: |
10.48350/169680 |
URI: |
https://boris.unibe.ch/id/eprint/169680 |
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