Can MRI differentiate between ring-enhancing gliomas and intra-axial abscesses?

Carloni, Andrea; Bernardini, Marco; Mattei, Chiara; De Magistris, Angela Vittoria; Llabres-Diaz, Francisco; Williams, Jonathan; Gutierrez-Quintana, Rodrigo; Oevermann, Anna; Schweizer-Gorgas, Daniela; Finck, Cyrielle; Masseau, Isabelle; Lorenzo, Valentina; Sabatini, Annalisa; Contiero, Barbara; Specchi, Swan (2022). Can MRI differentiate between ring-enhancing gliomas and intra-axial abscesses? Veterinary radiology & ultrasound, 63(5), pp. 563-572. Wiley 10.1111/vru.13098

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Gliomas of the brain may appear as expansile ring-enhancing masses in MRI studies, mimicking the appearance of intra-axial abscesses. The aims of this study were to compare the MRI features of ring-enhancing gliomas and intra-axial brain abscesses in dogs and cats and to identify the characteristics that might help differentiate them. For this multicenter, retrospective, and observational study, the inclusion criteria were as follows: (a) a definitive diagnosis of glioma or abscess based on cytological or histopathological examination following CSF collection or surgical biopsy/necropsy, respectively; (b) MRI study performed with a high- or low-field MRI scanner, including a same plane T1W pre- and postcontrast, a T2W and a T2 FLAIR sequence in at least one plane. If available, delayed T1W postcontrast, T2*W GE, DWI/ADC, and SWI sequences were also evaluated. Sixteen patients were diagnosed with ring-enhancing gliomas, and 15 were diagnosed with intra-axial abscesses. A homogenous signal on T1W (P = 0.049) and T2W (P = 0.042) sequences, a T2W (P = 0.005) or T2*W GE (P = 0.046) peripheral hypointense halo, and an even enhancing capsule (P = 0.002) were significantly associated with brain abscesses. A progressive central enhancement on delayed T1W postcontrast sequences was correlated with ring-enhancing gliomas (P = 0.009). The combination of the following features was suggestive of brain abscess: homogeneous T1W or T2W signal intensity, a T2W or T2*W GE peripheral hypointense halo and an evenly enhancing capsule. Central progression of enhancement on delayed T1W postcontrast sequences was suggestive of glioma.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research

UniBE Contributor:

Oevermann, Anna, Schweizer, Daniela Esther

Subjects:

600 Technology > 630 Agriculture

ISSN:

1740-8261

Publisher:

Wiley

Language:

English

Submitter:

Pubmed Import

Date Deposited:

06 May 2022 10:35

Last Modified:

05 Dec 2022 16:19

Publisher DOI:

10.1111/vru.13098

PubMed ID:

35509117

Uncontrolled Keywords:

brain cat dog infection neoplasia

BORIS DOI:

10.48350/169773

URI:

https://boris.unibe.ch/id/eprint/169773

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