[Fecal Microbiota Transfer (FMT) in Children and Adolescents - Review and statement by the GPGE microbiome working group].

Joachim, Alexander; Schwerd, Tobias; Hölz, Hannes; Sokollik, Christiane; Konrad, Lukas Alfons; Jordan, Alexander; Lanzersdorfer, Roland; Schmidt-Choudhury, Anjona; Hünseler, Christoph; Adam, Rüdiger (2022). [Fecal Microbiota Transfer (FMT) in Children and Adolescents - Review and statement by the GPGE microbiome working group]. Zeitschrift für Gastroenterologie, 60(6), pp. 963-969. Thieme 10.1055/a-1801-0284

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The human microbiome and especially the gastrointestinal microbiota are associated with health and disease. Disturbance in the composition or function of fecal microbiota (dysbiosis) plays a role in the development of pediatric gastrointestinal diseases. Fecal microbiota transfer (FMT) is a special intervention, where microbiota are transferred from a healthy donor.In this review we describe the current state of knowledge for FMT in pediatric patients. There is satisfactory evidence concerning FMT in patients with recurrent C. difficile infection. For inflammatory bowel disease, few studies show a potential benefit.Adverse events occurred frequently in clinical studies, but were mostly mild and transient. There are hardly any data on long-term side effects of FMT, which are particularly significant for pediatrics. In practice, there is uncertainty as to which application route, dosage or frequency should be used. Legally, donor stool is considered a drug in German-speaking countries, for which no marketing authorization exists.In conclusion, knowledge about physiology, efficacy and side effects of FMT is insufficient and legal concerns complicate its implementation. More studies on this topic are needed urgently.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Gastroenterology
UniBE Contributor:	Sokollik, Christiane
Subjects:	600 Technology > 610 Medicine & health
ISSN:	0044-2771
Publisher:	Thieme
Language:	German
Submitter:	Anette van Dorland
Date Deposited:	10 May 2022 09:33
Last Modified:	05 Dec 2022 16:19
Publisher DOI:	10.1055/a-1801-0284
PubMed ID:	35533688
URI:	https://boris.unibe.ch/id/eprint/169870