A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions [meeting summary].

Dellon, Evan S; Khoury, Paneez; Muir, Amanda B; Liacouras, Chris A; Safroneeva, Ekaterina; Atkins, Dan; Collins, Margaret H; Gonsalves, Nirmala; Falk, Gary W; Spergel, Jonathan M; Hirano, Ikuo; Chehade, Mirna; Schoepfer, Alain M; Menard-Katcher, Calies; Katzka, David A; Bonis, Peter A; Bredenoord, Albert J; Geng, Bob; Jensen, Elizabeth T; Pesek, Robert D; ... (2022). A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions [meeting summary]. Gastroenterology, 163(1), pp. 59-76. Elsevier 10.1053/j.gastro.2022.03.025

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BACKGROUND & AIMS

Disease activity and severity of eosinophilic esophagitis (EoE) dictate therapeutic options and management, but the decision-making process for determining severity varies among practitioners. To reduce variability in practice patterns and help clinicians monitor the clinical course of the disease in an office setting, we aimed to create an international consensus severity scoring index for EoE.

METHODS

A multidisciplinary international group of adult and pediatric EoE researchers and clinicians, as well as non-EoE allergy immunology and gastroenterology experts, formed 3 teams to review the existing literature on histology, endoscopy, and symptoms of EoE in the context of progression and severity. A steering committee convened a 1-day virtual meeting to reach consensus on each team's opinion on salient features of severity across key clinicopathologic domains and distill features that would allow providers to categorize disease severity.

RESULTS

Symptom features and complications and inflammatory and fibrostenotic features on both endoscopic and histologic examination were collated into a simplified scoring system-the Index of Severity for Eosinophilic Esophagitis (I-SEE)-that can be completed at routine clinic visits to assess disease severity using a point scale of 0-6 for mild, 7-14 for moderate, and ≥15 for severe EoE.

CONCLUSIONS

A multidisciplinary team of experts iteratively created a clinically usable EoE severity scoring system denominated "I-SEE" to guide practitioners in EoE management by standardizing disease components reflecting disease severity beyond eosinophil counts. I-SEE should be validated and refined using data from future clinical trials and routine clinical practice to increase its utilization and functionality.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Safroneeva, Ekaterina

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0016-5085

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

25 May 2022 14:26

Last Modified:

28 Apr 2023 16:29

Publisher DOI:

10.1053/j.gastro.2022.03.025

Related URLs:

PubMed ID:

35606197

Additional Information:

Simultaneously published in the Journal of Allergy and Clinical Immunology

Uncontrolled Keywords:

Complications Endoscopy Eosinophilic Esophagitis Histology Severity Symptoms

BORIS DOI:

10.48350/170254

URI:

https://boris.unibe.ch/id/eprint/170254

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