Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours.

Boller, Danielle; Doepfner, Kathrin T; Laurentiis, Angela DE; Guerreiro, Ana S; Marinov, Marin; Shalaby, Tarek; Depledge, Paul; Robson, Anthony; Saghir, Nahid; Hayakawa, Masahiko; Kaizawa, Hiroyuki; Koizumi, Tomonobu; Ohishi, Takahide; Fattet, Sarah; Delattre, Olivier; Schweri-Olac, Anelia; Höland, Katrin; Grotzer, Michael A; Frei, Karl; Spertini, Olivier; ... (2022). Republication: Targeting PI3KC2β Impairs Proliferation and Survival in Acute Leukemia, Brain Tumours and Neuroendocrine Tumours. Anticancer research, 42(6), pp. 3217-3230. International Inst. of Anticancer Research 10.21873/anticanres.15812

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BACKGROUND

Eight human catalytic phosphoinositide 3-kinase (PI3K) isoforms exist which are subdivided into three classes. While class I isoforms have been well-studied in cancer, little is known about the functions of class II PI3Ks.

MATERIALS AND METHODS

The expression pattern and functions of the class II PI3KC2β isoform were investigated in a panel of tumour samples and cell lines.

RESULTS

Overexpression of PI3KC2β was found in subsets of tumours and cell lines from acute myeloid leukemia (AML), glioblastoma multiforme (GBM), medulloblastoma (MB), neuroblastoma (NB), and small cell lung cancer (SCLC). Specific pharmacological inhibitors of PI3KC2β or RNA interference impaired proliferation of a panel of human cancer cell lines and primary cultures. Inhibition of PI3KC2β also induced apoptosis and sensitised the cancer cells to chemotherapeutic agents.

CONCLUSION

Together, these data show that PI3KC2β contributes to proliferation and survival in AML, brain tumours and neuroendocrine tumours, and may represent a novel target in these malignancies.

Item Type:

 Journal Article (Original Article)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hämatologie / Onkologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hämatologie / Onkologie (Pädiatrie)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

UniBE Contributor:

 Schweri, Anelia, Arcaro, Alexandre

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 0250-7005

Publisher:

 International Inst. of Anticancer Research

Language:

 English

Submitter:

 Pubmed Import

Date Deposited:

 02 Jun 2022 14:12

Last Modified:

 05 Dec 2022 16:20

Publisher DOI:

 10.21873/anticanres.15812

PubMed ID:

 35641277

Uncontrolled Keywords:

 PI3KC2β acute leukemia brain tumours cell proliferation migration neuroendocrine tumours pharmacological inhibition

BORIS DOI:

 10.48350/170416

URI:

 https://boris.unibe.ch/id/eprint/170416

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