Lanzinger, Stefanie; Best, Frank; Bergmann, Tanja; Laimer, Markus; Lipovsky, Boris; Danne, Thomas; Zimny, Stefan; Bramlage, Peter; Meyhöfer, Svenja; Holl, Reinhard W (2022). Dynamics of HbA1c, BMI and rates of severe hypoglycemia in 4,434 adults with type 1 or type 2 diabetes after initiation of continuous glucose monitoring. Diabetes technology & therapeutics, 24(10), pp. 763-769. Mary Ann Liebert 10.1089/dia.2022.0063
|
Text
dia.2022.0063.pdf - Accepted Version Available under License Publisher holds Copyright. Download (816kB) | Preview |
BACKGROUND
Continuous glucose monitoring (CGM) might have beneficial effects on glycemic control and body-mass-index (BMI) in adults with type 1 (T1D) or type 2 diabetes (T2D).
METHODS
The diabetes prospective follow-up registry was used to identify individuals with T1D or T2D ≥18 years starting CGM management in 2015 or later and follow-up information available. HbA1c, BMI and event rates of severe hypoglycemia in the year prior to CGM start were compared to two follow-up periods: 1) CGM use for 3-6 months and 2) CGM use for >6 months. Repeated measurements linear and negative binomial regression were used (adjustment for sex, age at diabetes onset and baseline parameters) and stratified by diabetes type.
RESULTS
Mean follow-up time was 1.8 years in T1D (n=2,994) and 1.9 years in T2D (n=1,440). In T1D, adjusted mean HbA1c decreased significantly from 7.65% (95%-confidence interval: 7.62-7.68) at baseline to 7.54% (7.51-7.57) during follow-up. BMI increased slightly (baseline: 25.4 kg/m2 (25.3-25.5), follow-up >6 months: 25.8 kg/m2 (25.7-25.9)), whereas event rates of severe hypoglycemia were significantly lower after >6 months with CGM (9.0 events/100 PY (8.0-10.1)) compared to baseline (11.3 events/100 PY (10.4-12.2)) in adults with T1D. In T2D, HbA1c decreased from 7.21% (7.17-7.25) to 7.00% (6.95-7.04%) and BMI did not change after CGM initiation.
CONCLUSION
Our results provide real world evidence on CGM management in adult individuals with T1D or T2D. We suggest to strengthen patients' and physicians' readiness towards diabetes technology in T2D and more openness of health insurance to cover cost based on proven benefits.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition |
UniBE Contributor: |
Laimer, Markus |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1520-9156 |
Publisher: |
Mary Ann Liebert |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Jun 2022 09:40 |
Last Modified: |
04 Jun 2023 00:25 |
Publisher DOI: |
10.1089/dia.2022.0063 |
PubMed ID: |
35653726 |
BORIS DOI: |
10.48350/170426 |
URI: |
https://boris.unibe.ch/id/eprint/170426 |
Actions (login required)
 |
Edit item |