Zürcher, Aline; Knabben, Laura; Janka, Heidrun; Stute, Petra (2023). Influence of the levonorgestrel-releasing intrauterine system on the risk of breast cancer: a systematic review. Archives of gynecology and obstetrics, 307(6), pp. 1747-1761. Springer 10.1007/s00404-022-06640-y
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PURPOSE
The intention of this systematic review was to analyze the literature on breast cancer (BC) and the use of the levonorgestrel-releasing intrauterine system (LNG-IUS).
METHODS
The literature was searched in Medline, Embase, Cochrane Library, CINAHL, Web of Science and ClinicalTrials.com and included search terms related to breast cancer and LNG-IUS. After elimination of duplicates, 326 studies could be identified and were assessed according to inclusion and exclusion criteria. In the end, 10 studies met the defined criteria and were included in the systematic review.
RESULTS
6 out of the 10 selected studies were cohort studies, three were case-control studies and one a systematic review/meta-analysis. 6 found a positive association between BC and the use of LNG-IUS. One study only found an increased risk for invasive BC in the subgroup of women aged 40-45 years. In contrast, three studies showed no indication of a higher BC risk.
CONCLUSION
The results imply an increased BC risk in LNG-IUS users, especially in postmenopausal women and with longer duration of use. Positive effects of the LNG-IUS such as reduced risks for other hormonal cancers have been observed, were, however, not focus of this systematic review. The heterogeneity of the analyzed studies and vast number of confounding factors call for further investigations in this issue. Patients should be advised according to their individual risk profile and hormone-free alternatives may be considered for women with a history of BC.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 13 Central Units > Administrative Director's Office > University Library of Bern |
UniBE Contributor: |
Knabben, Laura Michelle Tatjana, Janka, Heidrun Ilonka, Stute, Petra |
Subjects: |
600 Technology > 610 Medicine & health 000 Computer science, knowledge & systems > 020 Library & information sciences |
ISSN: |
1432-0711 |
Publisher: |
Springer |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
22 Jun 2022 11:43 |
Last Modified: |
29 Apr 2023 00:11 |
Publisher DOI: |
10.1007/s00404-022-06640-y |
PubMed ID: |
35716207 |
Uncontrolled Keywords: |
Breast cancer Contraception Hormone replacement therapy Levonorgestrel Levonorgestrel-releasing intrauterine system Postmenopause Premenopause |
BORIS DOI: |
10.48350/170830 |
URI: |
https://boris.unibe.ch/id/eprint/170830 |
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