Bacterial infection-driven lymphomagenesis.

Vannata, Barbara; Pirosa, Maria Cristina; Bertoni, Francesco; Rossi, Davide; Zucca, Emanuele (2022). Bacterial infection-driven lymphomagenesis. Current opinion in oncology, 34(5), pp. 454-463. Lippincott Williams & Wilkins 10.1097/CCO.0000000000000886

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PURPOSE

The first convincing evidence for a causal relationship between bacterial infection and lymphomagenesis came from the link between gastric lymphoma and chronic Helicobacter pylori gastritis. This review will summarize the current epidemiological, clinical, and biological evidence of a causative role of bacteria in the development of malignant lymphomas, particularly, the extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue type.

RECENT FINDINGS

Other microorganisms have been associated with specific extranodal lymphoma sites with variable and not always definitive, evidence, including Chlamydia psittaci, Borrelia burgdorferi, Campylobacter jejuni and, most recently, Coxiella Burnetii. According to most plausible models, lymphoma growth is a consequence of continuous antigenic stimulation induced by chronic infection. However, some evidence of a direct oncogenic role of H. pylori has been provided, too.

SUMMARY

Lymphomas are not the result of a single cause but multifactorial diseases, influenced by a variety of genetic and environmental elements. Hence, ascertaining the specific contribution of bacterial infections is not always easy. Nevertheless, the eradication of the associated chronic infection may result in sustained lymphoma regression. Moreover, the association between infections and lymphoma may offer opportunities for reducing lymphoma incidence by preventing the predisposing infections or treating them early.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Zucca, Emanuele

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1040-8746

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Pubmed Import

Date Deposited:

27 Jul 2022 09:53

Last Modified:

05 Dec 2022 16:22

Publisher DOI:

10.1097/CCO.0000000000000886

PubMed ID:

35880463

BORIS DOI:

10.48350/171572

URI:

https://boris.unibe.ch/id/eprint/171572

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